Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomitapide
Drug ID BADD_D01311
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status Prescription
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09637
MeSH ID C473731
PubChem ID 9853053
TTD Drug ID D0H8VY
NDC Product Code Not Available
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C39H37F6N3O2
CAS Registry Number 182431-12-5
SMILES C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C (=O)NCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
TeratogenicityATP-binding cassette subfamily B member 1AQ9JK64Not Available26240881
TeratogenicityCytochrome P450 3A4P08684T3784826240881
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.0050.000483%Not Available
Blood triglycerides increased13.12.03.0010.000362%Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Breast cancer21.05.01.003; 16.10.01.0010.000181%Not Available
Bronchitis11.01.09.001; 22.07.01.0010.000483%
Burning sensation08.01.09.029; 17.02.06.0010.000181%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002--Not Available
Carotene decreased13.02.05.005--Not Available
Cellulitis23.09.01.001; 11.02.01.0010.000241%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.001328%Not Available
Chills15.05.03.016; 08.01.09.0010.000241%
Chromaturia20.02.01.0020.000181%
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Constipation07.02.02.0010.001388%
Coronary artery occlusion24.04.04.013; 02.02.01.0060.000121%Not Available
Cough22.02.03.0010.000905%
Death08.04.01.001--
Defaecation urgency07.02.04.0010.000121%Not Available
Dehydration14.05.05.0010.000422%
Depressed mood19.15.02.0010.000241%Not Available
Depression19.15.01.001--
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.0010.017137%
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.001388%
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