Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomefloxacin hydrochloride
Drug ID BADD_D01310
Description Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Indications and Usage For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
Marketing Status Discontinued
ATC Code J01MA07; S01AE04
DrugBank ID DB00978
KEGG ID D00873
MeSH ID C053091
PubChem ID 68624
TTD Drug ID D02KOF
NDC Product Code Not Available
Synonyms lomefloxacin | lomenfloxacin | 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid | lomefloxacin hydrochloride | Maxaquin | Logiflox | Ocacin | Okacin | Okacyn | SC 4711 | SC-4711 | Décalogiflox | NY 198 | NY-198
Chemical Information
Molecular Formula C17H20ClF2N3O3
CAS Registry Number 98079-52-8
SMILES CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Polyuria20.02.03.002--Not Available
Protein total decreased13.09.01.004--Not Available
Prothrombin time prolonged13.01.02.012--Not Available
Pruritus23.03.12.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pulmonary embolism22.06.02.001; 24.01.06.001--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Purpura23.06.01.004; 24.07.06.005; 01.01.04.003--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Respiratory depression17.02.05.047; 22.02.01.010--Not Available
Respiratory disorder22.02.07.002--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Seizure17.12.03.001--
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Skin exfoliation23.03.07.003--Not Available
Skin hyperpigmentation23.05.01.003--
Skin ulcer24.04.03.007; 23.07.03.003--
Somnolence19.02.05.003; 17.02.04.006--
Specific gravity urine abnormal13.13.02.010--Not Available
Sputum increased22.02.03.007--Not Available
Stevens-Johnson syndrome10.01.03.020; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Stomatitis07.05.06.005--
Strangury20.02.02.017--Not Available
Stridor22.04.02.003--
Syncope17.02.04.008; 02.01.02.008; 24.06.02.012--
Tachycardia02.03.02.007--Not Available
Tendonitis15.07.01.003; 12.01.07.007--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
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