Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lithium
Drug ID BADD_D01302
Description Lithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.
Indications and Usage Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
Marketing Status Not Available
ATC Code N05AN01
DrugBank ID DB01356
KEGG ID D08133
MeSH ID D008094
PubChem ID 3028194
TTD Drug ID D5MF8Y
NDC Product Code 0054-3527; 68094-757
Synonyms Lithium | Lithium-7 | Lithium 7
Chemical Information
Molecular Formula Li
CAS Registry Number 7439-93-2
SMILES [Li]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Blood gas and acid base analysesCatalaseP04762Not Available25933952
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal weight gain14.03.02.010--Not Available
Albuminuria20.02.01.001--Not Available
Alopecia23.02.02.001--
Anaesthesia17.02.07.002--Not Available
Arrhythmia02.03.02.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blindness17.17.01.003; 06.02.02.001--Not Available
Bradycardia02.03.02.002--Not Available
Choreoathetosis17.01.01.003--Not Available
Clonus17.02.05.002--Not Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Coordination abnormal17.02.02.004--Not Available
Dehydration14.05.05.001--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysarthria19.19.03.001; 17.02.08.001--
Dystonia17.01.03.001--Not Available
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram normal13.14.05.022--Not Available
Electrocardiogram T wave inversion13.14.05.007--Not Available
Electroencephalogram abnormal13.07.03.001--Not Available
Fatigue08.01.01.002--
Folliculitis23.09.04.007; 11.01.12.018--
Glycosuria20.02.01.005--
Goitre14.11.01.008; 05.02.01.001--Not Available
Hair texture abnormal23.02.06.004--
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