Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levonorgestrel
Drug ID BADD_D01281
Description Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available.[L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older emergency contraceptive regimens.[A181976,A181994,L7760]
Indications and Usage For the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
Marketing Status Prescription; OTC; Discontinued
ATC Code G03AC03; G03AD01
DrugBank ID DB00367
KEGG ID D00950
MeSH ID D016912
PubChem ID 13109
TTD Drug ID D0BA9U
NDC Product Code 50419-424; 73302-911; 22552-0047; 43386-622; 45541-1244; 51660-723; 12866-1010; 50419-422; 63190-0660; 63190-0130; 45541-1174; 65129-2003; 50090-1141; 62756-720; 58602-721; 16714-809; 50419-423; 66499-0018; 69536-162; 69536-146; 40032-622; 71205-361; 57297-852; 0113-2003; 65089-0036; 68071-4247; 58602-712; 0536-1142; 68071-4294; 64122-605; 44132-004; 50090-3830; 68180-853; 69536-200; 51508-012; 69536-103; 58602-841; 59057-002; 53104-7669; 62756-718; 62756-723; 69953-515; 68180-852; 70700-164; 69536-133; 71205-120; 59057-001; 50102-211; 0023-5858; 69953-616; 63190-0850; 68071-4126; 44132-012
Synonyms Levonorgestrel | l-Norgestrel | l Norgestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)- | D-Norgestrel | D Norgestrel | Microval | duofem | Microlut | Mirena | Norgeston | Norplant-2 | Norplant 2 | Norplant2 | NorLevo | Norplant | Plan B | Vikela | Cerazet | Capronor
Chemical Information
Molecular Formula C21H28O2
CAS Registry Number 797-63-7
SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Death08.04.01.001--
Decreased activity19.11.01.002; 08.01.01.0060.006254%Not Available
Decreased interest19.15.02.0040.008338%Not Available
Defaecation urgency07.02.04.0010.002085%Not Available
Dehydration14.05.05.001--
Depressed level of consciousness17.02.04.002--
Depressed mood19.15.02.0010.192817%Not Available
Depression19.15.01.0010.951579%
Depression suicidal19.15.01.0040.013549%Not Available
Dermal cyst23.10.02.001; 16.26.02.0010.002085%Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis contact12.03.01.040; 10.01.01.003; 23.03.04.004--Not Available
Dermoid cyst16.02.02.006; 03.05.01.0050.002085%Not Available
Device breakage27.01.03.001--Not Available
Device expulsion27.01.01.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.0020.161550%Not Available
Discomfort08.01.08.0030.185521%Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.002--
Disturbance in attention19.21.02.002; 17.03.03.0010.071916%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.480480%
Dizziness postural24.06.02.008; 17.02.05.004; 02.01.02.005--Not Available
Drug abuse19.07.02.010--Not Available
Drug dependence19.07.02.009--Not Available
Drug hypersensitivity10.01.01.001--Not Available
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
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