Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levetiracetam
Drug ID BADD_D01265
Description Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no potential to produce, or be subject to, pharmacokinetic interactions[L8606,L8600,L8615] - these characteristics make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions.[A185927]
Indications and Usage Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AX14
DrugBank ID DB01202
KEGG ID D00709
MeSH ID D000077287
PubChem ID 5284583
TTD Drug ID D0E1XL
NDC Product Code 76282-247; 65162-538; 28877-5960; 50474-001; 68180-113; 63739-411; 69367-333; 51991-651; 68001-114; 70518-1921; 51927-0107; 42385-957; 0409-1886; 60505-3517; 16714-034; 70518-1796; 63629-8315; 55111-870; 60687-249; 24689-106; 51552-1448; 50474-597; 47335-576; 16714-358; 55154-7887; 50474-596; 55154-5782; 43485-104; 72865-188; 69102-106; 0121-0799; 63629-4675; 51672-4136; 63323-400; 65841-703; 0378-5617; 0904-6051; 68001-117; 66689-028; 68084-859; 13668-017; 43547-346; 14789-110; 0378-5613; 55111-182; 25021-780; 12666-0014; 68382-168; 52343-071; 16714-355; 35208-031; 13668-016; 16571-788; 43547-221; 31722-574; 68180-112; 65862-245; 54838-548; 63629-4137; 42185-7039; 10370-195; 10370-214; 0121-2397; 61919-559; 0409-2011; 16571-787; 68180-114; 43547-223; 66689-029; 43063-499; 76494-530; 66174-0044; 47133-574; 52343-072; 72789-152; 75834-246; 52038-171; 60505-3518; 80705-101; 76282-246; 76494-529; 71930-063; 51927-0088; 68083-153; 71052-043; 69076-500; 38779-2900; 68001-402; 44567-501; 50090-4023; 70860-602; 16714-357; 64980-365; 65862-247; 62331-010; 0904-7060; 68084-882; 51672-4141; 50474-599; 68083-152; 47335-573; 68554-0065; 68001-115; 67457-790; 68084-870; 55154-5699; 0615-7978; 0121-4799; 71093-144; 43485-102; 64980-363; 65162-529; 0378-5615; 65162-528; 16729-065; 70518-2320; 63187-360; 43485-103; 69102-107; 0904-7124; 50228-190; 0904-6052; 72189-190; 50090-3518; 71930-065; 68001-405; 0143-9574; 16571-789; 67296-1248; 70518-0947; 55111-183; 63739-787; 36998-0117; 68180-117; 65862-261; 55154-3367; 71335-0139; 64980-362; 16714-310; 17856-0574; 68084-893; 72865-189; 0904-7123; 60432-831; 43547-222; 60429-349; 50228-189; 68071-4508; 68180-118; 0395-8160; 50268-470; 71930-062; 50090-2456; 36998-5980; 69339-157; 64220-192; 68788-7074; 13668-014; 72485-106; 69367-332; 35208-032; 55111-248; 61919-068; 65372-1148; 16714-035; 36998-5950; 28877-5970; 69076-750; 70518-1969; 51672-4142; 68083-154; 52343-069; 52343-070; 50474-598; 65862-315; 51672-4137; 61919-552; 36998-5960; 51927-0155; 72643-025; 71901-605; 16571-790; 81414-001; 44567-502; 71205-880; 65841-704; 68382-165; 66689-030; 0904-7125; 68001-404; 70166-081; 51927-4721; 63629-7516; 58032-0132; 55154-7647; 13668-015; 43063-617; 50383-241; 69102-108; 67296-1636; 51079-821; 50090-2875; 16714-356; 36998-5970; 65862-246; 0472-0235; 43489-122; 69102-105; 81646-116; 62756-880; 50090-3264; 50228-472; 71335-0748; 71335-0048; 0121-1598; 75834-245; 68001-118; 14789-330; 71930-064; 61919-685; 14789-220; 50090-3889; 81665-100; 50474-594; 68001-113; 16714-354; 16729-067; 57572-0034; 63739-019; 55150-177; 42385-955; 65162-685; 58118-1112; 68788-7430; 42385-956; 76282-248; 70518-2810; 50228-473; 50090-1333; 67835-0006; 71335-0702; 70518-3317; 31722-539; 68180-115; 67457-266; 31722-538; 71335-0694; 64220-152; 66689-102; 43547-224; 47133-575; 36998-5990; 64376-697; 50474-002; 16729-064; 39822-4000; 76494-531; 70860-604; 62512-0030; 43547-345; 42385-954; 72640-004; 0615-7979; 80705-100; 51672-4143; 70860-603; 76494-528; 50090-5495; 44567-500; 50090-5760; 67457-265; 65162-539; 64980-364; 68001-116; 43489-124; 72969-039; 16729-066; 68788-7884; 72865-187; 68180-099; 72189-229; 70518-2230; 0615-7976; 0378-5619; 36998-5940; 31722-536; 43485-101; 68788-7534; 55111-181; 72865-190; 51224-013; 42571-331; 70518-1998; 60429-350; 0904-6053; 67457-255; 63629-2073; 70518-2328; 65862-250; 50474-595; 50683-0322; 60505-3280; 70518-1901; 62350-0059; 0143-9673; 31722-537; 68001-403; 71205-881; 70518-3192; 44567-503; 55289-097; 28877-5950; 63739-795; 68225-021; 0615-7977; 16714-537
Synonyms Levetiracetam | Etiracetam, S-isomer | Etiracetam, S isomer | S-isomer Etiracetam | Ucb L059 | Ucb-L059 | UCB 6474 | UCB-6474 | UCB6474 | Etiracetam, R-isomer | Etiracetam, R isomer | R-isomer Etiracetam | Etiracetam, (R)- | Keppra | Etiracetam | alpha-ethyl-2-oxo-1-Pyrrolidineacetamide | alpha ethyl 2 oxo 1 Pyrrolidineacetamide | Ucb L060 | Ucb-L060 | UcbL060
Chemical Information
Molecular Formula C8H14N2O2
CAS Registry Number 102767-28-2
SMILES CCC(C(=O)N)N1CCCC1=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.001391%Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebral palsy18.04.04.004; 17.19.03.002; 03.10.03.0020.000381%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.001--Not Available
Cholangitis09.02.01.002--Not Available
Cholecystitis09.03.01.001--
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.0010.006665%Not Available
Choreoathetosis17.01.01.0030.000571%Not Available
Chromaturia20.02.01.002--
Circulatory collapse24.06.02.0010.000795%Not Available
Cleft lip07.05.08.002; 15.11.05.002; 03.11.05.0020.001143%Not Available
Cleft lip and palate07.05.08.003; 03.04.02.0030.002095%Not Available
Cleft palate07.05.08.001; 03.04.02.0010.001143%Not Available
Clonus17.02.05.0020.001333%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.004--Not Available
Clumsiness17.01.02.0050.001904%Not Available
Coagulopathy01.01.02.0010.001904%Not Available
Coarctation of the aorta03.07.08.001; 24.04.01.0020.000447%Not Available
Coma17.02.09.0010.006284%Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Complex partial seizures17.12.02.0030.000762%Not Available
Confusional state19.13.01.001; 17.02.03.0050.014663%
Congenital central nervous system anomaly17.19.01.003; 03.10.02.0040.001143%Not Available
Congenital megacolon07.02.05.005; 03.04.04.0020.000381%Not Available
Conjoined twins18.03.02.010; 03.02.01.0090.000149%Not Available
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