Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Latanoprost
Drug ID BADD_D01251
Description Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment.[A184493] It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as [Timolol]. Another benefit latanoprost is that it can be administered once a day.[A184490]
Indications and Usage For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Marketing Status Prescription; Discontinued
ATC Code S01EE01
DrugBank ID DB00654
KEGG ID D00356
MeSH ID D000077338
PubChem ID 5311221
TTD Drug ID D0C6NM
NDC Product Code 90027-006; 68071-2376; 59762-0333; 47335-317; 24208-463; 63190-0710; 65326-004; 45542-1156; 0009-5172; 51927-4864; 42385-039; 55545-0462; 71684-0547; 45542-1159; 68071-4893; 12079-0475; 64980-516; 50090-1920; 61314-547; 51927-0091; 68245-0002; 71205-154; 65035-128; 51552-1385; 17478-625; 46144-156; 65862-872; 40016-001; 71052-041; 61919-112; 65727-026; 61556-050; 65427-007; 81997-001; 68071-4650; 51927-0090; 24002-0018; 54893-0010; 10695-048; 0013-8303; 82231-111; 68071-4612; 70069-421
Synonyms Latanoprost | PhXA34 | PHXA41 | Xalatan
Chemical Information
Molecular Formula C26H40O5
CAS Registry Number 130209-82-4
SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eye disorder06.08.03.0010.002139%Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.000450%Not Available
Eye infection11.01.06.001; 06.04.05.0070.000788%
Eye inflammation06.04.05.0020.000788%Not Available
Eye irritation06.04.05.0030.021950%Not Available
Eye pain06.08.03.0020.010694%
Eye swelling06.08.03.0030.002364%Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.000788%Not Available
Eyelid ptosis06.05.01.002; 17.17.02.0040.000450%Not Available
Faeces discoloured07.01.03.0020.000225%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.000901%Not Available
Foreign body in eye12.01.04.012; 06.11.01.0050.000338%Not Available
Fracture15.08.02.001; 12.04.02.0010.000225%
Gait disturbance17.02.05.016; 08.01.02.002--
Glaucoma06.03.01.0020.003602%
Hair colour changes23.02.06.001--
Hallucination, visual19.10.02.0040.000225%Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.000225%Not Available
Heart rate increased13.14.04.0020.000450%Not Available
Heart rate irregular13.14.04.0030.000225%Not Available
Hepatic function abnormal09.01.02.001--Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hordeolum11.01.06.002; 06.04.04.0060.000338%Not Available
Hyperaemia24.03.02.002--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.0030.002251%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 10 Pages