Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lansoprazole
Drug ID BADD_D01245
Description Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole.[A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies caused by excessive acid secretion.[A177053]
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BC03
DrugBank ID DB00448
KEGG ID D00355
MeSH ID D064747
PubChem ID 3883
TTD Drug ID D06YYD
NDC Product Code 60687-111; 0113-7116; 68788-6390; 71335-0575; 38779-2289; 71335-0043; 0363-4069; 65015-658; 46122-698; 65628-080; 64764-046; 0093-7350; 11532-1441; 49035-373; 53104-7526; 62175-415; 72288-343; 52932-0730; 11673-117; 70700-263; 66332-1443; 0093-3009; 64679-140; 0904-6662; 55111-044; 64679-669; 49452-3041; 43598-560; 41520-816; 67877-275; 63629-2342; 59779-117; 67877-274; 11532-1440; 63629-4851; 68071-3019; 55111-399; 69256-401; 50090-4596; 50090-5180; 42291-433; 31722-571; 49348-301; 30142-288; 49711-0110; 0378-8015; 72288-829; 0113-0116; 68071-4456; 68382-772; 41250-391; 72288-301; 51838-123; 70700-262; 42765-023; 72476-020; 70771-1132; 68788-7742; 0378-8030; 0536-1324; 41250-117; 70677-0124; 31722-570; 59349-0015; 0536-1236; 63629-7552; 64764-541; 68071-5119; 63739-555; 71335-0917; 71052-242; 62175-430; 62756-252; 61919-890; 51927-3877; 68382-771; 68071-2274; 68001-111; 60687-123; 65841-770; 41163-117; 63981-582; 11822-0117; 62011-0472; 63187-510; 11822-3374; 69842-270; 62175-515; 70000-0508; 0781-2148; 0113-6002; 55154-0253; 63629-2340; 50090-2225; 55289-704; 56062-283; 27241-020; 36800-392; 0113-0117; 30142-117; 70771-1133; 72189-279; 71335-1820; 49035-739; 71335-1425; 79903-068; 27241-019; 0363-0739; 52562-021; 43598-561; 55111-739; 68788-7789; 30142-192; 63415-0060; 65372-1136; 63187-152; 45865-879; 45802-878; 65977-0013; 11673-280; 56062-117; 69842-755; 0781-2147; 50090-3195; 37012-117; 43598-883; 0067-6286; 16714-186; 62011-0168; 66332-1442; 42291-365; 51079-121; 68391-117; 80425-0174; 63850-3309; 63629-2341; 55910-117; 68001-112; 16571-698; 0378-6981; 63868-429; 0378-6982; 71335-1521; 46122-107; 16714-185; 64764-543; 16571-697; 36800-295; 51552-1239; 64764-544; 51927-0064; 0093-3008; 21130-181; 55154-4848; 57896-761; 63981-117; 42291-364; 55910-307; 45802-245; 69842-507; 64679-670; 16571-742; 68382-543; 0363-1419; 81522-001; 70000-0069; 68016-758; 80425-0148; 68382-544; 70756-806; 70756-807; 0113-1114; 0093-7351; 71335-0058; 42291-434; 41163-150; 68788-7385; 0378-3995; 51407-324; 65841-769; 49035-411; 72189-062; 37808-755; 64374-007; 0113-7003; 55111-398; 61919-245; 61919-655; 0363-1212; 60760-544; 36800-117; 71335-0105
Synonyms Lansoprazole | Lansoprazol | 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole | Lansoprazoles | Ogastro | AG 1749 | AG-1749 | AG1749 | Agopton | Bamalite | Lansol | Lansoprazole Sodium | Sodium, Lansoprazole | Lanzor | Monolitum | Opiren | Prevacid | Pro Ulco | Promeco | Takepron | Ulpax | Zoton | Ogast | Prezal
Chemical Information
Molecular Formula C16H14F3N3O2S
CAS Registry Number 103577-45-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Duodenal ulcer07.04.02.0020.000838%
Duodenitis07.08.03.001--Not Available
Dysarthria19.19.03.001; 17.02.08.0010.001257%
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.006--
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.0010.003143%
Dysphagia07.01.06.0030.002724%
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.0040.001257%
Dyspnoea22.02.01.004; 02.01.03.0020.015923%
Dystonia17.01.03.0010.001257%Not Available
Dysuria20.02.02.0020.000838%
Ear disorder04.03.01.001--Not Available
Eczema23.03.04.0060.000419%
Electrocardiogram QT prolonged13.14.05.0040.002095%
Electrolyte imbalance14.05.01.0020.001048%Not Available
Embolic stroke24.01.04.010; 17.08.01.0320.000419%Not Available
Enteritis07.08.03.002--
Enterocolitis haemorrhagic07.08.01.007; 24.07.02.0060.000419%Not Available
Eosinophil count increased13.01.06.0040.000219%Not Available
Eosinophilia01.02.04.0010.003352%
Epidermolysis bullosa23.03.01.010; 03.05.01.0010.000419%Not Available
Epilepsy17.12.03.0020.001048%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.0030.000419%
Erythema23.03.06.0010.010057%Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.000629%
Eye disorder06.08.03.001--Not Available
Eye pain06.08.03.0020.000629%
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.000629%Not Available
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