Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lamotrigine
Drug ID BADD_D01243
Description Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries.[A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring. While it is indicated for epilepsy and bipolar disorders, there is evidence that lamotrigine could have some clinical efficacy in certain neuropathic pain states.[A849,A850]
Indications and Usage Indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults (≥18 years of age) treated for acute mood episodes with standard therapy [FDA Label].
Marketing Status Prescription; Discontinued
ATC Code N03AX09
DrugBank ID DB00555
KEGG ID D00354
MeSH ID D000077213
PubChem ID 3878
TTD Drug ID D03FLC
NDC Product Code 29300-114; 13668-342; 0173-0779; 69102-312; 58437-021; 50228-319; 62332-038; 67835-0016; 68462-228; 55111-222; 61919-802; 65841-686; 69102-359; 51672-4139; 58437-023; 67877-166; 55700-683; 0173-0526; 59746-247; 65162-986; 50228-320; 0173-0699; 51407-062; 68382-006; 71335-1469; 0904-7008; 0115-1529; 65841-682; 68788-7544; 46708-276; 69102-137; 16714-893; 55111-720; 16714-700; 64679-275; 55111-043; 16714-701; 55289-410; 42291-443; 70518-1523; 53002-1512; 65862-362; 65015-626; 65841-687; 70518-2406; 65862-227; 69102-319; 43063-259; 59917-077; 42291-447; 68788-6868; 69097-148; 67877-165; 0173-0643; 70518-3109; 68382-010; 63187-744; 61919-534; 49884-487; 49884-486; 55111-428; 66406-0281; 60760-549; 68382-979; 0615-8267; 69097-152; 51927-0021; 29300-112; 43063-238; 71335-1919; 43598-551; 59917-078; 27241-183; 72888-028; 51407-063; 16714-196; 53002-2512; 70518-2535; 11014-0155; 27241-184; 76420-182; 0173-0776; 12658-0579; 72888-027; 70518-3150; 46708-274; 68382-108; 0615-7964; 69097-151; 65862-229; 55154-2330; 51672-4132; 59746-246; 46708-853; 65372-1103; 68382-011; 27241-186; 65862-228; 69918-360; 0173-0817; 58118-2148; 0173-0644; 72789-206; 12658-0578; 16714-623; 71335-1748; 70518-2563; 58437-022; 65841-689; 0173-0754; 71335-0830; 55111-718; 64679-274; 62332-037; 70518-2577; 51552-1361; 16571-785; 51672-4133; 55111-419; 55111-719; 69102-301; 70518-2645; 71335-0706; 50228-322; 63629-8283; 70518-2697; 43063-202; 0115-9940; 55111-221; 59917-079; 69918-370; 42291-369; 0115-1527; 50090-5567; 0173-0758; 51672-4140; 53747-016; 70518-2716; 70518-1908; 55111-226; 55154-2065; 58437-019; 60760-474; 68788-7871; 13668-045; 0173-0774; 0228-1453; 13668-049; 17511-103; 68382-009; 65841-683; 14799-2011; 68382-981; 0615-8150; 68382-980; 53296-0059; 16714-703; 16714-624; 0173-0633; 0395-8217; 0173-0760; 55111-717; 69097-149; 65862-361; 68382-982; 12666-0005; 67877-164; 16714-627; 69918-380; 72888-025; 65841-684; 0904-7007; 42291-446; 65862-266; 70518-3139; 66406-0284; 50090-2130; 58437-020; 49884-881; 63187-487; 72189-063; 13668-341; 68788-7223; 0228-1435; 13668-266; 71335-1110; 0115-9941; 16714-702; 0115-9942; 70518-1479; 50090-4939; 55111-223; 51672-4130; 70518-2889; 62332-040; 68788-7168; 69918-350; 0173-0642; 63629-4697; 0173-0781; 71335-0044; 69102-150; 50090-3914; 55154-2331; 62332-096; 62332-039; 16714-195; 51407-060; 53104-7606; 59746-248; 65162-990; 71205-245; 11014-0157; 0173-0755; 16714-194; 69102-300; 49884-882; 70518-3187; 0173-0778; 0228-1410; 66406-0282; 65162-988; 65841-685; 0115-9939; 50090-5828; 13668-340; 62331-047; 72888-026; 68382-983; 51407-061; 13668-048; 27241-185; 55111-220; 65862-230; 64679-273; 62332-095; 68382-109; 0228-1580; 60760-050; 49884-484; 42291-368; 49711-0111; 16714-626; 0173-0759; 43598-550; 69102-306; 49884-880; 53002-1513; 64679-272; 43598-553; 68022-7036; 59285-023; 68382-984; 0173-0777; 50090-2129; 64679-271; 58437-024; 68462-229; 0228-1638; 67877-167; 43598-552; 16714-625; 0173-0757; 59917-080; 58118-1111; 71335-1179; 65162-949; 0173-0756; 66406-0283; 71335-1579; 49884-485; 70518-3043; 0115-1526; 16714-197; 68382-008; 13668-339; 65162-956; 0228-1422; 69102-639; 50228-321; 53002-2513; 59746-245; 13668-047; 68084-319; 46708-275; 42291-366; 42419-012; 0173-0527; 0173-0761; 65162-958; 50090-5827; 46708-277; 0173-0780; 70518-2503; 55700-626; 29300-111; 16571-786; 65841-690; 68382-007; 42291-444; 51672-4131; 68084-318; 0115-1528; 70518-1978; 42291-448; 69102-320; 50090-2131; 0615-7975; 0173-0772; 43063-203; 50090-5850; 55111-225; 29300-113; 68788-7647; 11014-0154; 42291-445; 70518-2755; 42291-367; 0173-0594; 11014-0156
Synonyms Lamotrigine | 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine | 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine | Lamictal | Crisomet | Lamiktal | BW-430C | BW 430C | BW430C | Labileno
Chemical Information
Molecular Formula C9H7Cl2N5
CAS Registry Number 84057-84-1
SMILES C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Epilepsy17.12.03.0020.017271%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Epstein-Barr virus infection11.05.10.0040.000644%
Eructation07.01.02.003--
Erythema23.03.06.0010.014048%Not Available
Erythema annulare23.03.08.0040.000387%Not Available
Erythema multiforme10.01.03.015; 23.03.01.0030.004898%
Erythema of eyelid23.03.06.006; 06.04.04.0030.001289%Not Available
Euphoric mood19.04.02.0060.000516%
Exomphalos07.16.03.002; 03.04.07.0010.000773%Not Available
Extrapyramidal disorder17.01.02.007--
Extrasystoles02.03.02.0030.000773%Not Available
Eye discharge06.04.05.0010.001418%Not Available
Eye disorder06.08.03.0010.000902%Not Available
Eye inflammation06.04.05.0020.000258%Not Available
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.0020.002191%
Eye swelling06.08.03.0030.001418%Not Available
Eyelid oedema23.04.01.003; 06.04.04.004; 10.01.05.0010.001547%Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.0020.007346%
Facial pain08.01.08.0120.001160%
Facial paralysis17.04.03.0080.000387%Not Available
Faeces discoloured07.01.03.002--Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000387%Not Available
Fallot's tetralogy03.07.06.001; 02.08.01.0020.000516%Not Available
Fatigue08.01.01.002--
Fear19.06.03.001--Not Available
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
The 10th Page    First    Pre   10 11 12 13 14    Next   Last    Total 43 Pages