Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lamivudine
Drug ID BADD_D01242
Description A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Indications and Usage For the treatment of HIV infection and chronic hepatitis B (HBV).
Marketing Status Prescription
ATC Code J05AF05
DrugBank ID DB00709
KEGG ID D00353
MeSH ID D019259
PubChem ID 60825
TTD Drug ID D07TQV
NDC Product Code 60505-3250; 53873-075; 53873-073; 55773-0589; 49702-204; 49702-203; 50742-623; 65015-701; 68180-603; 50742-624; 65862-259; 53873-074; 54838-566; 31722-752; 64380-711; 49702-205; 31722-001; 70159-001; 52482-003; 64380-710; 31722-753; 68554-0043; 65862-026; 33342-001; 69097-167; 70518-3267; 57237-274; 65015-756; 70518-2067; 70518-2070; 67835-0017; 0173-0662; 53104-7538; 60687-362; 0173-0663; 60505-3252; 53104-7677; 65862-025; 68180-602; 65862-055; 68554-0016; 66993-478; 31722-754; 65862-577; 69097-166; 42385-714; 33342-002; 60505-3251; 60429-354; 60429-353; 0904-6583
Synonyms Lamivudine | 3TC | 2',3'-Dideoxy-3'-thiacytidine | 2',3' Dideoxy 3' thiacytidine | Epivir | Lamivudine, (2S-cis)-Isomer | BCH-189 | BCH 189 | BCH189 | GR-109714X | GR109714X
Chemical Information
Molecular Formula C8H11N3O3S
CAS Registry Number 134678-17-4
SMILES C1C(OC(S1)CO)N2C=CC(=NC2=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Platelet count13.01.04.011--Not Available
Pleural effusion22.05.02.002--
Pleuritic pain22.02.04.0080.009276%
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumothorax22.05.02.0030.011595%
Pollakiuria20.02.02.007--
Polydactyly15.11.07.010; 03.11.07.0100.004638%Not Available
Polyneuropathy17.09.03.0120.004638%Not Available
Polyuria20.02.03.002--Not Available
Postpartum haemorrhage24.07.03.003; 18.06.01.0010.009276%Not Available
Pregnancy18.08.02.004--Not Available
Premature baby18.04.02.0010.016233%Not Available
Premature delivery18.07.01.0060.013914%
Productive cough22.02.03.0050.009276%
Progressive multifocal leukoencephalopathy17.16.02.002; 11.05.05.0010.004638%Not Available
Proteinuria20.02.01.0110.004638%
Pruritus23.03.12.001--
Pulmonary congestion24.03.08.001; 22.01.03.002; 02.05.02.0020.001815%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.0030.011595%
Pulmonary tuberculosis11.04.01.003; 22.07.06.0020.009276%Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.0030.004638%Not Available
Rash maculo-papular23.03.13.0040.009276%
Rash pruritic23.03.12.0020.004638%Not Available
Rash pustular11.01.12.002; 23.03.10.0030.004638%
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Renal failure20.01.03.0050.008469%Not Available
Renal tubular disorder20.05.03.0040.011595%Not Available
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