Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lamivudine
Drug ID BADD_D01242
Description A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Indications and Usage For the treatment of HIV infection and chronic hepatitis B (HBV).
Marketing Status Prescription
ATC Code J05AF05
DrugBank ID DB00709
KEGG ID D00353
MeSH ID D019259
PubChem ID 60825
TTD Drug ID D07TQV
NDC Product Code 60505-3250; 53873-075; 53873-073; 55773-0589; 49702-204; 49702-203; 50742-623; 65015-701; 68180-603; 50742-624; 65862-259; 53873-074; 54838-566; 31722-752; 64380-711; 49702-205; 31722-001; 70159-001; 52482-003; 64380-710; 31722-753; 68554-0043; 65862-026; 33342-001; 69097-167; 70518-3267; 57237-274; 65015-756; 70518-2067; 70518-2070; 67835-0017; 0173-0662; 53104-7538; 60687-362; 0173-0663; 60505-3252; 53104-7677; 65862-025; 68180-602; 65862-055; 68554-0016; 66993-478; 31722-754; 65862-577; 69097-166; 42385-714; 33342-002; 60505-3251; 60429-354; 60429-353; 0904-6583
Synonyms Lamivudine | 3TC | 2',3'-Dideoxy-3'-thiacytidine | 2',3' Dideoxy 3' thiacytidine | Epivir | Lamivudine, (2S-cis)-Isomer | BCH-189 | BCH 189 | BCH189 | GR-109714X | GR109714X
Chemical Information
Molecular Formula C8H11N3O3S
CAS Registry Number 134678-17-4
SMILES C1C(OC(S1)CO)N2C=CC(=NC2=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eye irritation06.04.05.0030.004638%Not Available
Fanconi syndrome20.05.03.009; 14.01.01.011; 03.06.01.0010.004638%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Femur fracture15.08.03.003; 12.04.01.003--Not Available
Fibrosis08.03.01.0010.016233%Not Available
Flatulence07.01.04.002--
Folliculitis23.09.04.007; 11.01.12.018--
Fungal skin infection23.09.02.001; 11.03.05.002--Not Available
Gait disturbance17.02.05.016; 08.01.02.0020.013914%
Gastritis07.08.02.0010.006957%
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal infection11.01.07.012; 07.19.02.005--Not Available
Gastrointestinal pain07.01.05.005--
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Graft versus host disease12.02.09.001; 10.02.01.0270.001815%Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Haemoglobin13.01.05.018--Not Available
Hallucination19.10.02.002--
Hallucination, auditory19.10.02.0030.004638%Not Available
Headache17.14.01.001--
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.001815%Not Available
Hepatic failure09.01.03.0020.006654%
Hepatic fibrosis24.08.06.002; 09.01.04.0020.004638%Not Available
Hepatic function abnormal09.01.02.0010.034784%Not Available
Hepatic steatosis14.08.04.005; 09.01.07.003--Not Available
Hepatitis09.01.07.0040.013914%Not Available
Hepatitis A11.05.06.003; 09.01.09.0040.013914%Not Available
Hepatitis acute09.01.07.0050.018551%Not Available
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