Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketorolac tromethamine
Drug ID BADD_D01233
Description Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.[L6358][L6508][L11055][L3674][L11070] It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis.[L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.[L6511]
Indications and Usage For the short-term (~5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting.
Marketing Status Prescription; Discontinued
ATC Code M01AB15; S01BC05
DrugBank ID DB00465
KEGG ID D00813
MeSH ID D020911
PubChem ID 84003
TTD Drug ID Not Available
NDC Product Code 70518-2927; 0023-2181; 25021-700; 71205-582; 35356-696; 72611-719; 0404-9952; 60687-104; 0409-3796; 60505-1003; 0023-9277; 0338-0076; 71872-7212; 63278-1056; 68083-132; 51662-1488; 35573-450; 50090-2746; 0409-3795; 0404-9884; 50090-4635; 50090-5428; 71205-594; 63323-162; 70518-3308; 45865-613; 71872-7118; 70860-701; 70529-119; 0487-6232; 0404-9883; 50090-4583; 51655-170; 69344-144; 55154-0120; 63323-161; 71872-7234; 72266-119; 68788-8149; 0338-0072; 71872-7132; 61919-138; 66267-418; 63629-2488; 71872-7131; 65862-775; 55150-340; 50090-5013; 70529-121; 70529-120; 80425-0139; 60760-314; 12711-5990; 71872-7213; 62991-2818; 68083-103; 25021-701; 55154-1555; 66993-193; 50090-2762; 68083-134; 76420-250; 72189-335; 71872-7119; 0395-8216; 71872-7022; 43235-0001; 55289-328; 42571-137; 0641-6043; 68071-1787; 55154-9366; 52584-725; 64679-758; 0093-0314; 0641-6041; 55154-9368; 72611-725; 71205-116; 71335-1904; 17478-207; 55154-6960; 69543-388; 71872-7185; 70860-700; 68071-2576; 53069-0620; 14501-0010; 67296-1412; 0641-6042; 76045-107; 0338-0069; 50090-3397; 72189-054; 55154-1556; 68083-104; 72611-722; 68071-2443; 64679-757; 47335-221; 63187-628; 72266-118; 51662-1295; 0409-3793; 55150-341; 50090-3364; 70518-0048; 66267-832; 71872-7188; 51927-0111; 71335-1803; 76045-209; 53002-6990; 63187-128; 51552-1371; 53002-7780; 76420-032; 51927-3443; 76045-104; 70518-2610; 60758-773; 49452-3926; 66577-045; 55154-9398; 63629-2974; 49711-0103; 42291-358; 50090-5609; 0023-3507; 68071-4811; 61314-126; 50090-0601; 55150-339; 66022-0117; 70529-122; 43063-904; 65044-7424; 55111-014; 49452-3919; 76420-252; 71205-296; 68788-7517; 51662-1292; 68071-2400; 47335-219; 47335-220; 38779-2249; 52584-722; 70518-3369; 0378-1134; 66577-016; 68083-133; 68071-2569; 17478-209; 50090-3550; 52584-719; 63187-777; 76045-105; 76420-184; 65862-770; 17478-208; 68071-2252
Synonyms Ketorolac Tromethamine | Acular | Toradol
Chemical Information
Molecular Formula C19H24N2O6
CAS Registry Number 74103-07-4
SMILES C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Melaena24.07.02.013; 07.12.02.004--Not Available
Meningitis aseptic17.06.03.002; 11.01.03.002--Not Available
Mental disability26.01.01.001--Not Available
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Metabolic acidosis14.01.01.003--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle twitching15.05.03.005--Not Available
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal dryness22.04.03.002--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nephritis20.05.02.001--Not Available
Nephrotic syndrome20.05.01.002--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oesophagitis07.08.05.001--
Oliguria20.01.03.004--Not Available
Oral pain07.05.03.002--
Osteoarthritis15.01.04.001--Not Available
Pain08.01.08.004--
Pallor24.03.04.001; 08.01.03.032; 23.03.03.031--Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.002--Not Available
Pancytopenia01.03.03.003--Not Available
Panophthalmitis06.04.05.005--Not Available
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