Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketorolac
Drug ID BADD_D01232
Description Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.[L6358][L6508][L11055][L3674][L11070] It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis.[L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.[L6511]
Indications and Usage For the short-term (~5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting.
Marketing Status Not Available
ATC Code M01AB15; S01BC05
DrugBank ID DB00465
KEGG ID D08104
MeSH ID D020910
PubChem ID 3826
TTD Drug ID D0D9JW
NDC Product Code Not Available
Synonyms Ketorolac
Chemical Information
Molecular Formula C15H13NO3
CAS Registry Number 74103-06-3
SMILES C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal failure20.01.03.0050.000120%Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Rhinorrhoea22.02.05.0100.000919%
Seizure17.12.03.001--
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.0040.000120%Not Available
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.0060.000689%
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Stomatitis07.05.06.005--
Stupor17.02.04.007; 19.02.05.004--Not Available
Swelling face23.04.01.018; 10.01.05.0180.000689%Not Available
Swollen tongue10.01.05.015; 07.14.02.003; 23.04.01.0140.000459%Not Available
Syncope17.02.04.008; 24.06.02.012; 02.01.02.0080.000459%
Tachycardia02.03.02.0070.000459%Not Available
Tension19.06.02.005--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Thirst08.01.09.021; 14.03.02.007--Not Available
Throat irritation22.02.05.013; 07.05.03.0040.001148%Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue disorder07.14.01.002--Not Available
Tongue oedema07.14.02.007; 23.04.01.009; 10.01.05.008--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Tremor17.01.06.002--
Ulcer08.03.06.001--Not Available
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.0010.002526%
Vascular purpura24.07.06.011; 23.06.01.008; 01.01.04.007--Not Available
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