Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketoprofen
Drug ID BADD_D01231
Description Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications and Usage For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Marketing Status Prescription; Discontinued
ATC Code M01AE03; M02AA10
DrugBank ID DB01009
KEGG ID D00132
MeSH ID D007660
PubChem ID 3825
TTD Drug ID D0W9WF
NDC Product Code 49452-3917; 68981-031; 82348-102; 0276-0504; 12660-0006; 69336-127; 12854-516; 43235-0010; 63275-9996; 51927-0057; 76465-0001; 51927-0025; 51552-0307; 63187-018; 38779-0078; 51927-0231; 0395-8056; 45865-485; 38779-3039; 49452-3924; 0378-8200; 79572-019; 51604-0011
Synonyms Ketoprofen | Benzoylhydratropic Acid | 2-(3-Benzoylphenyl)propionic Acid | Profenid | Alrheumum | Orudis | 19,583 RP | RP, 19,583 | RP-19583 | RP 19583 | RP19583 | Alrheumat
Chemical Information
Molecular Formula C16H14O3
CAS Registry Number 22071-15-4
SMILES CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Gastrointestinal toxicityTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
Gastrointestinal toxicityGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal impairment20.01.03.010--Not Available
Erosive oesophagitis07.04.05.0040.008278%Not Available
Liver injury12.01.02.003; 09.01.07.0220.020695%Not Available
Hypertransaminasaemia09.01.02.0050.016556%Not Available
Anorectal discomfort07.03.03.003--Not Available
Intestinal steatosis07.11.01.011; 14.08.04.016--Not Available
Kounis syndrome24.04.04.020; 10.01.03.037; 02.02.02.0200.012417%Not Available
Acute kidney injury20.01.03.0160.053806%
Drug-induced liver injury09.01.07.023; 12.03.01.0440.020695%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.020695%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.002159%
Ductus arteriosus stenosis foetal24.03.03.027; 03.07.09.0060.003239%Not Available
Meningitis pneumococcal17.06.10.004; 11.02.06.0120.003239%Not Available
Nephritis allergic20.05.01.018; 10.01.03.0440.012417%Not Available
Ductus arteriosus premature closure24.03.03.026; 18.04.07.006; 03.07.09.005; 02.08.01.0050.002159%Not Available
Abscess neck15.03.03.007; 11.01.17.0040.012417%Not Available
Laryngeal discomfort22.02.05.0400.008278%Not Available
Palatal oedema07.05.04.0080.016556%Not Available
Sopor19.02.04.002; 17.02.04.0210.008278%Not Available
Dermo-hypodermitis23.09.01.021; 11.01.12.0210.016556%Not Available
Tongue pruritus07.14.02.0210.008278%Not Available
Brain empyema17.06.07.004; 11.01.03.0090.003239%Not Available
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