Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Itraconazole
Drug ID BADD_D01217
Description One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
Indications and Usage For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Marketing Status Prescription; Discontinued
ATC Code J02AC02
DrugBank ID DB01167
KEGG ID D00350
MeSH ID D017964
PubChem ID 55283
TTD Drug ID D0V4IB
NDC Product Code 12578-299; 50268-450; 53069-0450; 58032-0110; 0378-5100; 68382-697; 66577-044; 63629-8168; 60687-299; 10147-0150; 70518-3264; 50458-290; 62991-3078; 10147-1700; 71747-002; 65162-630; 67835-5043; 16729-271; 10695-064; 22568-1108; 67877-454; 31722-006; 65162-087; 46708-204; 38779-2759; 62332-204; 60592-318; 72761-019; 70771-1208; 49884-239; 70518-2872; 66039-815; 17511-114; 50458-295; 59349-0012; 13668-463; 0395-8113; 71052-301; 50546-462; 16714-743; 51552-0920; 65015-624; 51862-462
Synonyms Itraconazole | R-51211 | R 51211 | R51211 | Sporanox | Orungal
Chemical Information
Molecular Formula C35H38Cl2N8O4
CAS Registry Number 84625-61-6
SMILES CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C 7=C(C=C(C=C7)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Malaise08.01.01.003--
Mania19.16.02.0020.009282%
Memory impairment19.20.01.003; 17.03.02.003--
Menopausal symptoms21.02.02.002--Not Available
Menstrual disorder21.01.01.0040.013924%Not Available
Metabolic alkalosis14.01.02.0040.009282%Not Available
Mouth ulceration07.05.06.004--Not Available
Mucosal inflammation08.01.06.002--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.0010.023206%
Myocarditis02.04.03.0010.013924%
Myopathy15.05.05.0010.013924%Not Available
Nasopharyngitis22.07.03.002; 11.01.13.0020.013924%Not Available
Nausea07.01.07.0010.148518%
Nephropathy toxic20.05.03.002; 12.03.01.0100.013924%Not Available
Nervous system disorder17.02.10.0010.010897%Not Available
Neuropathy peripheral17.09.03.0030.055694%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.023206%Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.0060.027847%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.064977%
Onychomycosis23.09.02.007; 11.03.05.007--Not Available
Orthopnoea02.01.03.006; 22.02.01.0200.003632%Not Available
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Osteomyelitis11.01.01.001; 15.02.05.0010.009282%
Osteoporotic fracture15.08.02.007; 14.04.04.007; 12.04.02.0050.009282%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.0100.027847%
Palpitations02.01.02.0030.041771%
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