Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isosorbide dinitrate
Drug ID BADD_D01210
Description A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Indications and Usage For the prevention of angina pectoris due to coronary artery disease.
Marketing Status Prescription; Discontinued
ATC Code C01DA08; C05AE02
DrugBank ID DB00883
KEGG ID D00516
MeSH ID D007548
PubChem ID 6883
TTD Drug ID D0I1SK
NDC Product Code 49884-020; 0143-1769; 51407-149; 0781-1695; 43353-141; 0615-8294; 16714-008; 16714-010; 70710-1148; 70518-0063; 70518-2306; 70710-1149; 0187-0192; 0781-1635; 0143-1772; 70771-1502; 70710-1152; 70771-1501; 0615-8157; 70771-1505; 46438-0634; 55154-7990; 50268-448; 49884-009; 0781-1556; 55154-7991; 68001-374; 68084-083; 0143-1771; 70518-1435; 43353-139; 63629-2573; 0904-6619; 51407-147; 50268-447; 63739-569; 42291-350; 16714-007; 70710-1150; 49884-556; 51407-148; 70771-1504; 70518-2817; 16714-009; 0615-8193; 0187-0152; 70710-1151; 0904-6620; 68001-375; 46438-0001; 63739-367; 50268-449; 68001-373; 70771-1503; 68084-082; 68682-192; 68682-193; 49884-021; 49884-022
Synonyms Isosorbide Dinitrate | Dinitrate, Isosorbide | Dilatrate | Iso-Bid | Iso Bid | IsoBid | Isodinit | Isoket | Sorbonit | Isomak R | Isordil | Isotrate | Nitrosorbide | Sorbitrate | Cardonit 40 | Isoket Retard-120 | Isoket Retard 120 | Isoket Retard120
Chemical Information
Molecular Formula C6H8N2O8
CAS Registry Number 87-33-2
SMILES C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angina pectoris24.04.04.002; 02.02.02.002--
Angina unstable02.02.02.004; 24.04.04.004--Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.0050.001803%Not Available
Blood pressure abnormal13.14.03.001--Not Available
Blood pressure decreased13.14.03.0020.008114%Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure02.05.01.0010.003058%
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.0010.001803%
Heart rate increased13.14.04.0020.005410%Not Available
Hypersensitivity10.01.03.0030.001803%
Hypertension24.08.02.001--
Hypotension24.06.03.0020.004508%
Loss of consciousness17.02.04.004--Not Available
Methaemoglobinaemia01.05.01.002--
Myocardial ischaemia24.04.04.010; 02.02.02.0080.003293%Not Available
Nausea07.01.07.0010.002705%
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Rash23.03.13.001--Not Available
Shock24.06.02.002--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Vasodilatation24.03.02.003; 23.06.05.006--Not Available
Vomiting07.01.07.0030.002705%
Withdrawal hypertension24.08.02.009; 08.06.02.007--Not Available
Silent myocardial infarction24.04.04.025; 02.02.02.0220.015327%Not Available
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