Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isosorbide
Drug ID BADD_D01209
Description Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [isosorbide dinitrate] forms, and is used for the prevention of angina. Refer to these drug entries for more information.
Indications and Usage
Marketing Status Discontinued
ATC Code Not Available
DrugBank ID DB09401
KEGG ID D00347
MeSH ID D007547
PubChem ID 12597
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms Isosorbide | Dianhydrosorbitol
Chemical Information
Molecular Formula C6H10O4
CAS Registry Number 652-67-5
SMILES C1C(C2C(O1)C(CO2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Heart sounds abnormal13.14.01.002--Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypernatraemia14.05.04.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hyperuricaemia14.09.01.003--
Hypoaesthesia17.02.06.023--Not Available
Hypochromic anaemia01.03.02.004--Not Available
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Influenza like illness08.01.03.010--
Insomnia19.02.01.002; 17.15.03.002--
Intermittent claudication24.04.03.001--Not Available
Irritability19.04.02.013; 08.01.03.011--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Libido decreased21.03.02.005; 19.08.03.001--
Loss of consciousness17.02.04.004--Not Available
Lung infiltration22.01.02.004--Not Available
Malaise08.01.01.003--
Melaena24.07.02.013; 07.12.02.004--Not Available
Menopausal symptoms21.02.02.002--Not Available
Mental disability26.01.01.001--Not Available
Mental impairment17.03.03.002; 19.21.02.003--Not Available
Methaemoglobinaemia01.05.01.002--
Migraine24.03.05.003; 17.14.02.001--Not Available
Mood swings19.04.03.001--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
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