Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isoniazid
Drug ID BADD_D01204
Description Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Indications and Usage For the treatment of all forms of tuberculosis in which organisms are susceptible.
Marketing Status Prescription; Discontinued
ATC Code J04AC01
DrugBank ID DB00951
KEGG ID D00346
MeSH ID D007538
PubChem ID 3767
TTD Drug ID D09XQF
NDC Product Code 71610-108; 50090-1490; 60687-553; 43063-463; 71052-611; 50090-0370; 12785-0002; 50090-0410; 0527-1109; 53002-2920; 71335-0275; 68788-9405; 71610-395; 0555-0071; 46287-009; 63187-978; 12785-0003; 66639-914; 0781-3056; 0555-0066; 70518-0096; 70518-2576; 51079-083
Synonyms Isoniazid | Isonicotinic Acid Hydrazide | Hydrazide, Isonicotinic Acid | Phthivazide | Phthivazid | Isonicotinic Acid Vanillylidenehydrazide | Acid Vanillylidenehydrazide, Isonicotinic | Vanillylidenehydrazide, Isonicotinic Acid | Ftivazide | Tubazide | Isonex
Chemical Information
Molecular Formula C6H7N3O
CAS Registry Number 54-85-3
SMILES C1=CN=CC=C1C(=O)NN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityCatalaseP04762Not Available26004706
HepatotoxicityN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
HepatotoxicityOmega-amidase NIT2Q9JHW2Not Available26004706
HepatotoxicityGlutathione peroxidase 1P04041Not Available26004706
HepatotoxicityAlanine aminotransferase 1P24298Not Available4000989; 707874; 110184
HepatotoxicityN-alpha-acetyltransferase 20P61599Not AvailableNot Available
HepatotoxicityAlbuminP02770Not Available26004706
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not AvailableNot Available
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema multiforme23.03.01.003; 10.01.03.0150.025481%
Extradural haematoma17.08.05.001; 24.07.04.002; 12.01.10.0020.012741%Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.031851%
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.003324%Not Available
Fanconi syndrome14.01.01.011; 03.06.01.001; 20.05.03.0090.025481%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling drunk08.01.09.0150.019111%Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.0110.012741%
Gastrointestinal disorder07.11.01.0010.031851%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.0020.210219%Not Available
Glomerulonephritis minimal lesion20.05.01.0110.031851%Not Available
Glossodynia07.14.02.001--Not Available
Glycosuria20.02.01.0050.012741%
Gynaecomastia21.05.04.003; 05.05.02.003--
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin decreased13.01.05.0030.031851%Not Available
Haemoglobinuria20.02.01.017; 01.06.04.005--
Haemolysis01.06.04.002--
Haemolytic anaemia01.06.03.002--Not Available
Haemoptysis02.01.02.006; 24.07.01.006; 22.02.03.0040.012741%Not Available
Hallucinations, mixed19.10.02.0070.012741%Not Available
Headache17.14.01.001--
Heart rate increased13.14.04.0020.019111%Not Available
Hepatic atrophy09.01.08.0040.003324%Not Available
Hepatic cirrhosis09.01.04.0010.006647%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.063703%Not Available
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