Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Indinavir
Drug ID BADD_D01150
Description A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Indications and Usage Indinavir is an antiretroviral drug for the treatment of HIV infection.
Marketing Status Prescription; Discontinued
ATC Code J05AE02
DrugBank ID DB00224
KEGG ID C07051
MeSH ID D019469
PubChem ID 5362440
TTD Drug ID D0V7CF
NDC Product Code Not Available
Synonyms Indinavir | MK-639 | MK 639 | MK639 | L-735 524 | L 735 524 | L735 524 | L-735,524 | L 735,524 | L735,524 | Crixivan | Indinavir Sulfate | Sulfate, Indinavir | Indinavir, Sulfate (1:1)
Chemical Information
Molecular Formula C36H47N5O4
CAS Registry Number 150378-17-9
SMILES CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC= C5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Insulin resistanceAP-2 complex subunit betaP63010Not Available10566684; 10996400; 15865214; 14523274
Insulin resistanceLipoprotein lipaseP06858T2869210566684; 10996400; 15865214; 14523274
Insulin resistanceAdiponectinQ15848T1557210566684; 10996400; 15865214; 14523274
Therapeutic and nontherapeutic responsesCytochrome P450 3A4P08684T378488805725; 8805726; 7489857; 8614120
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Viral diarrhoea11.05.04.012; 07.19.02.008--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Lymphatic disorder01.09.01.003--Not Available
Musculoskeletal stiffness15.03.01.005--Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhage24.07.01.002--Not Available
Paraesthesia oral17.02.06.008; 07.05.03.003--Not Available
Anxiety disorder19.06.01.002--Not Available
Connective tissue disorder15.06.01.006--Not Available
Inflammation08.01.05.007--Not Available
Lipomatosis14.08.04.011--Not Available
Malnutrition14.03.02.004--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.049--Not Available
Blood disorder01.05.01.004--Not Available
Autoimmune disorder10.04.04.003--
Haemophilia03.15.01.006; 01.01.01.009--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Urine analysis abnormal13.13.02.008--Not Available
Renal impairment20.01.03.010--Not Available
Sinus disorder22.04.06.002--
Regurgitation07.01.07.004--Not Available
Acute kidney injury20.01.03.016--
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