Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status approved; investigational
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 66215-303; 40016-013; 82231-109; 54893-0017; 66215-302
UNII JED5K35YGL
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.0070.000082%
Fluid retention20.01.02.003; 14.05.06.0020.001151%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.000428%
Gait disturbance15.03.05.013; 08.01.02.002; 17.02.05.0160.000592%
Gamma-glutamyltransferase increased13.03.04.024--
Gastric haemorrhage24.07.02.007; 07.12.01.0010.000082%
Gastric ulcer07.04.03.0020.000123%
Gastritis07.08.02.0010.000123%
Gastrointestinal disorder07.11.01.001--Not Available
Generalised oedema14.05.06.007; 08.01.07.0040.000247%
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Glaucoma06.03.01.0020.000123%
Glossitis07.14.01.001--Not Available
Glossodynia07.14.02.001--Not Available
Gout15.01.06.001; 14.09.01.0010.000082%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000329%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.000206%Not Available
Haemoglobin13.01.05.018--Not Available
Haemoptysis22.02.03.004; 02.11.04.009; 24.07.01.0060.000658%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Haemorrhage subcutaneous23.06.07.002; 24.07.06.0100.000082%Not Available
Headache17.14.01.0010.003035%
Hemiparesis17.01.04.0010.000082%
Hepatic cirrhosis09.01.04.0010.000164%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.000082%Not Available
Hepatic neoplasm16.07.03.001; 09.04.03.0010.000164%Not Available
Hernia08.01.04.0010.000123%Not Available
Hypersensitivity10.01.03.003--
Hypersomnia19.02.05.001; 17.15.01.0010.000164%
Hypervolaemia02.05.04.019; 14.05.06.0030.000123%Not Available
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