Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloperidone
Drug ID BADD_D01134
Description Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals gave the Phase III development rights to Vanda Pharmaceuticals. FDA approved on May 9, 2009.
Indications and Usage Treatment of acute schizophrenia.
Marketing Status Prescription
ATC Code N05AX14
DrugBank ID DB04946
KEGG ID D02666
MeSH ID C081732
PubChem ID 71360
TTD Drug ID D0M8VE
NDC Product Code 51672-4178; 51672-4181; 43068-112; 43068-108; 43068-902; 43068-106; 51672-4183; 66499-0042; 46016-1332; 43068-104; 66022-0115; 63285-756; 43068-101; 50379-0006; 63285-755; 43068-901; 43068-903; 66499-0067; 51672-4180; 51672-4213; 43068-102; 51672-4179; 51672-4182; 51672-4184; 43068-110; 43068-113
Synonyms iloperidone | Fanapt | HP 873 | HP-873 | Zomaril
Chemical Information
Molecular Formula C24H27FN2O4
CAS Registry Number 133454-47-4
SMILES CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Akathisia19.06.02.006; 17.01.02.0020.000602%
Amenorrhoea21.01.02.001; 05.05.01.002--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Anorgasmia19.08.01.001--
Aphthous ulcer07.05.06.002--Not Available
Arrhythmia02.03.02.0010.000602%Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block first degree02.03.01.004--
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blood pressure decreased13.14.03.0020.000602%Not Available
Body temperature increased13.15.01.001--Not Available
Bradykinesia17.01.02.004--Not Available
Breast pain21.05.05.003--
Bulimia nervosa19.09.01.006; 14.03.03.001--Not Available
Cardiac failure02.05.01.001--
Cataract06.06.01.001--
Catatonia19.11.01.0010.000602%Not Available
Cheilitis23.03.03.025; 07.05.01.001--
Cholelithiasis09.03.01.002--Not Available
Coma17.02.09.0010.000602%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.000157%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis06.04.01.002; 11.01.06.012--
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