Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Icodextrin
Drug ID BADD_D01124
Description Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport via peritoneal lymphatic pathways.
Indications and Usage Used for continuous ambulatory peritoneal dialysis (CAPD) of diabetic patients or automated peritoneal dialysis (APD) for the management of end-stage renal disease.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB00702
KEGG ID D03266
MeSH ID D000077607
PubChem ID 3517
TTD Drug ID D02YCH
NDC Product Code 66127-100
UNII 2NX48Z0A9G
Synonyms Icodextrin | Extraneal | Icodial
Chemical Information
Molecular Formula C8H8Cl2N4
CAS Registry Number 5051-62-7
SMILES C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypervolaemia02.05.04.019; 14.05.06.003--Not Available
Hypocalcaemia14.04.01.004--
Hypochloraemia14.05.08.003--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypoglycaemic coma17.02.09.005; 14.06.03.004; 05.06.03.004--Not Available
Hypokalaemia14.05.03.002--
Hypomagnesaemia14.04.02.001--
Hyponatraemia14.05.04.002--
Hypoproteinaemia14.10.01.003; 09.01.02.004--Not Available
Hypotension24.06.03.002--
Hypovolaemia14.05.05.002--Not Available
Ileus07.13.01.001--
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Influenza11.05.03.001; 22.07.02.001--Not Available
Inguinal hernia07.16.02.001--Not Available
Injury12.01.08.004--Not Available
Instillation site pain12.07.01.008; 08.02.01.008--Not Available
Intestinal obstruction07.13.01.002--Not Available
Laboratory test abnormal13.18.01.001--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.004--Not Available
Lung disorder22.02.07.001--Not Available
Malaise08.01.01.003--
Mental disability26.01.01.001--Not Available
Muscle spasms15.05.03.004--
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