Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ibritumomab tiuxetan
Drug ID BADD_D01118
Description Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light chains of 213 amino acids each.
Indications and Usage For treatment of non-Hodgkin's lymphoma
Marketing Status Prescription
ATC Code V10XX02
DrugBank ID DB00078
KEGG ID D04489
MeSH ID C422802
PubChem ID 92002593
TTD Drug ID Not Available
NDC Product Code 72893-007
Synonyms ibritumomab tiuxetan | Zevalin | yttrium-90-ibritumomab tiuxetan | IDEC-Y2B8 | IDEC-Y2B8 IDEC-129 | IDEC-129
Chemical Information
Molecular Formula C24H35N5O11
CAS Registry Number 206181-63-7
SMILES CC(CN(CC(CC1=CC=C(C=C1)NC(=O)NC)N(CC(=O)O)CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaemia01.03.02.001--
Asthenia08.01.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cough22.02.03.001--
Dermatitis bullous23.03.01.002--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Epistaxis22.04.03.001; 24.07.01.005--
Erythema multiforme23.03.01.003; 10.01.03.015--
Extravasation08.01.03.008--Not Available
Fatigue08.01.01.002--
Hypertension24.08.02.001--
Influenza like illness08.01.03.010--
Laryngeal pain22.02.05.036--
Leukopenia01.02.02.001--Not Available
Lymphopenia01.02.02.002--Not Available
Myalgia15.05.02.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Night sweats23.02.03.006; 08.01.03.031--Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Radiation injury12.05.02.003--Not Available
Rash23.03.13.001--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
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