Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroxyurea
Drug ID BADD_D01110
Description An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indications and Usage For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Marketing Status Prescription; Discontinued
ATC Code L01XX05
DrugBank ID DB01005
KEGG ID D00341
MeSH ID D006918
PubChem ID 3657
TTD Drug ID D07CWD
NDC Product Code 70518-0916; 0904-6939; 51927-0072; 49452-3650; 0003-6337; 60429-265; 55154-7143; 0003-0830; 10135-702; 71770-120; 49884-724; 55512-0003; 68084-284; 51552-0851; 17337-0022; 0003-6336; 35369-0006; 0555-0882; 0003-6335; 42291-321; 51927-2655; 71052-323; 69315-164; 17337-0023; 71770-105
Synonyms Hydroxyurea | Hydroxycarbamid | Oncocarbide | Hydrea
Chemical Information
Molecular Formula CH4N2O2
CAS Registry Number 127-07-1
SMILES C(=O)(N)NO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chronic myeloid leukaemiaTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
HepatomegalyTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Normochromic normocytic anaemia01.03.02.0050.000533%Not Available
Oedema14.05.06.010; 08.01.07.0060.001598%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.001332%
Oesophageal carcinoma07.21.06.001; 16.13.06.0010.000139%Not Available
Oesophageal varices haemorrhage24.07.02.022; 09.01.06.004; 07.12.01.0030.000208%
Oligohydramnios18.05.01.0010.000533%Not Available
Oligospermia21.03.03.005--
Osteomyelitis15.02.05.001; 11.01.01.0010.000139%
Oxygen saturation decreased13.02.01.0040.001066%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palmar-plantar erythrodysaesthesia syndrome23.07.04.001; 17.02.07.009--
Palpitations02.01.02.0030.001066%
Pancreatic carcinoma16.13.10.001; 07.21.09.0020.000278%Not Available
Pancreatitis07.18.01.0010.000799%
Pancreatitis acute07.18.01.0020.000799%Not Available
Pancytopenia01.03.03.0030.003197%Not Available
Papule23.03.03.038--Not Available
Pericarditis02.06.02.0010.000799%
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.0020.000533%Not Available
Plasma cell myeloma16.23.02.004; 01.14.02.004--Not Available
Platelet count decreased13.01.04.0010.013321%
Platelet disorder01.08.03.0010.000799%Not Available
Pleural effusion22.05.02.0020.001598%
Pneumonia22.07.01.003; 11.01.09.0030.008525%Not Available
Pneumonia aspiration22.01.01.0050.000208%Not Available
Pneumonia respiratory syncytial viral22.07.05.005; 11.05.13.0020.000139%Not Available
Pneumonitis22.01.01.0060.001332%
Polycythaemia01.07.01.0010.000533%Not Available
Polycythaemia vera01.13.03.002; 16.21.03.0030.000417%Not Available
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