Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocortisone
Drug ID BADD_D01086
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Marketing Status Prescription; Discontinued
ATC Code A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
DrugBank ID DB00741
KEGG ID D00088
MeSH ID D006854
PubChem ID 5754
TTD Drug ID D0KR5B
NDC Product Code 73921-017; 68071-2233; 55910-225; 0168-0146; 64958-0036; 43136-203; 11673-842; 37946-7517; 0009-0012; 41167-0331; 76314-004; 45802-438; 38779-0009; 73921-015; 62011-0095; 73014-3050; 36800-981; 10631-407; 60722-1001; 41167-0108; 71863-109; 76420-028; 45802-937; 41167-0335; 0536-1277; 0113-0973; 41250-887; 62742-4077; 73408-633; 41167-0336; 68788-9922; 69473-017; 51326-108; 72189-276; 45334-327; 0009-5275; 68726-123; 47682-397; 68981-002; 41163-471; 11673-057; 69103-4506; 62559-431; 61269-343; 71516-001; 69729-103; 51672-2013; 68071-2546; 76420-161; 59088-268; 50382-024; 49035-732; 0009-0044; 21130-395; 63015-242; 41167-0339; 41520-201; 41167-0105; 51672-3004; 51672-3003; 62172-203; 59762-0073; 69842-809; 0395-8146; 68071-2261; 72789-227; 64958-0096; 42543-142; 41250-369; 72336-120; 45802-276; 62559-138; 55670-800; 67510-0065; 59779-878; 0096-0732; 63868-689; 0363-0670; 61010-4402; 68016-009; 24286-1560; 71216-3006; 65649-501; 70288-173; 73408-933; 49967-108; 60687-511; 82298-101; 41163-369; 70000-0543; 45865-630; 47682-398; 63629-2528; 62011-0096; 41167-0342; 11673-353; 42543-140; 41167-0039; 69396-069; 11673-399; 41415-047; 0472-0345; 50090-3434; 50090-0244; 36800-099; 24385-190; 0316-0186; 49035-707; 68062-9103; 50090-3115; 37946-7520; 37808-471; 0113-0541; 55910-646; 63629-8666; 68071-4878; 37946-6449; 53002-9660; 81238-4608; 11822-0680; 63941-312; 66267-969; 70518-3275; 68016-909; 69842-292; 0113-7006; 65649-401; 50090-3113; 69396-005; 72789-228; 63941-229; 67234-010; 69315-312; 55718-160; 69396-081; 59256-004; 41163-319; 68071-5205; 41415-048; 55621-001; 0574-0420; 50090-4094; 21130-278; 30142-369; 63629-2529; 21130-369; 53943-986; 55910-541; 53329-091; 69396-003; 37808-319; 0316-0128; 41167-0036; 63187-543; 63629-8335; 72789-229; 68788-9800; 69315-302; 45802-014; 50090-0350; 69729-269; 71863-111; 0316-0291; 43742-0563; 69396-028; 53145-430; 41520-319; 58624-0702; 68391-100; 68788-8078; 0472-0337; 43749-621; 62559-430; 37946-6503; 0363-1973; 79481-0319; 63187-575; 24385-274; 53943-269; 0009-0069; 64380-970; 0115-1696; 36800-051; 77052-010; 21130-993; 67510-0632; 57582-013; 76314-002; 67060-370; 72663-493; 11822-0499; 11822-0416; 68196-973; 0472-0339; 24385-021; 72288-369; 61919-364; 51927-0143; 41167-0035; 69842-345; 53002-8350; 50090-5856; 64958-0062; 79503-202; 63629-8667; 63629-8817; 0472-0343; 63187-504; 69396-096; 0168-0020; 71863-112; 63187-480; 71205-571; 58624-0703; 0179-8711; 76420-031; 65923-035; 42543-970; 68062-9108; 42543-141; 55315-181; 0316-0193; 71399-0120; 65923-393; 51822-021; 37946-7522; 11673-030; 72789-095; 68071-1581; 63629-1952; 41250-259; 59779-099; 53943-984; 51672-2063; 42213-370; 0168-0015; 63629-8668; 69396-017; 10356-120; 0573-0552; 41163-973; 53943-985; 0009-0031; 55621-018; 79481-8224; 66406-0050; 61010-5800; 51824-050; 50090-5470; 24385-276; 0904-7188; 0115-1700; 62135-020; 44577-623; 79572-018; 61269-345; 0363-0791; 71335-0812; 50090-2452; 63736-339; 50090-0527; 0404-0370; 51927-0144; 51927-0224; 43749-250; 37946-7518; 49348-441; 70000-0495; 79481-0471; 0316-0126; 69396-055; 59762-0074; 37808-973; 70934-350; 11822-2099; 73622-3050; 51672-2010; 76314-003; 71399-1246; 68016-063; 64025-0001; 36800-524; 43742-1275; 71399-0180; 79481-0973; 47682-933; 67091-419; 65923-925; 55700-321; 30142-541; 79903-091; 43749-620; 59762-0075; 69396-050; 0115-1697; 58624-0700; 30142-411; 71205-034; 36800-059; 55910-319
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C21H30O5
CAS Registry Number 50-23-7
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
InflammationInterleukin-8P10145T226589169777; 12871375; 10348705; 9435641; 9631245; 12538206; 8902882; 15383152; 9717082
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myocardial rupture12.01.11.002; 02.04.02.002--Not Available
Myopathy15.05.05.001--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.0020.000447%Not Available
Nausea07.01.07.001--
Neck pain15.03.04.0090.000335%
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neoplasm malignant16.16.01.0010.000058%Not Available
Nervous system disorder17.02.10.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.0030.000224%Not Available
Nitrogen balance negative13.13.01.010--Not Available
Oedema14.05.06.010; 08.01.07.0060.000335%Not Available
Oesophageal candidiasis11.03.03.008; 07.19.06.001--Not Available
Oesophageal ulcer07.04.05.002--
Oesophagitis07.08.05.001--
Opportunistic infection11.01.08.007--Not Available
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.002--Not Available
Oral candidiasis11.03.03.004; 07.05.07.0010.000224%Not Available
Osteoarthritis15.01.04.001--Not Available
Osteonecrosis24.04.05.004; 15.02.04.0070.000447%
Osteoporosis15.02.03.002; 14.04.04.002--
Pain08.01.08.0040.000783%
Pain in extremity15.03.04.0100.000559%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.000335%Not Available
Palpitations02.01.02.0030.000447%
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.002--Not Available
Pancreatitis haemorrhagic07.18.01.003--Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.002--
Paraesthesia17.02.06.0050.000447%
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