Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocodone
Drug ID BADD_D01084
Description Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations. Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.[L9025]
Indications and Usage For relief of moderate to moderately severe pain. Also used for the symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants.
Marketing Status Discontinued; Prescription
ATC Code R05DA03
DrugBank ID DB00956
KEGG ID D08045
MeSH ID D006853
PubChem ID 5284569
TTD Drug ID D0X5KF
NDC Product Code 81842-617
Synonyms Hydrocodone | Hydrocodon | Dihydrocodeinone | Dicodid | Robidone | Hydrocodone Bitartrate | Hydrocodone Tartrate (1:1), Hydrate (2:5) | Hydrocodeinonebitartrate | Hydrocon | Codinovo | Hycodan | Hycon
Chemical Information
Molecular Formula C18H21NO3
CAS Registry Number 125-29-1
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Feeling cold08.01.09.0080.000436%Not Available
Foot fracture15.08.03.012; 12.04.01.012--Not Available
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.0010.001599%
Heart rate increased13.14.04.0020.000291%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.000436%
Hypersensitivity10.01.03.0030.001454%
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.0020.000581%
Laceration23.03.11.004; 12.01.06.006--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Ligament sprain15.07.02.004; 12.01.07.008--Not Available
Malaise08.01.01.0030.000581%
Menopausal symptoms21.02.02.002--Not Available
Migraine24.03.05.003; 17.14.02.0010.000291%Not Available
Mood swings19.04.03.001--Not Available
Muscle spasms15.05.03.0040.000291%
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Nasal congestion22.04.04.0010.000291%
Nausea07.01.07.0010.001599%
Neck pain15.03.04.009--
Nervous system disorder17.02.10.001--Not Available
Night sweats23.02.03.006; 08.01.03.031--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.0110.000291%
Osteoarthritis15.01.04.001--Not Available
Pain08.01.08.0040.001454%
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