Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Hydrochlorothiazide
Drug ID BADD_D01083
Description Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444]
Indications and Usage Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy.[L8447,L8450] Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.[A185138,L8447,L8450]
Marketing Status approved; vet_approved
ATC Code C03AA03
DrugBank ID DB00999
KEGG ID D00340
MeSH ID D006852
PubChem ID 3639
TTD Drug ID D0U4UQ
NDC Product Code 65862-113; 42708-079; 0172-2089; 50090-1088; 50090-6158; 51655-272; 53002-4970; 57237-002; 62135-448; 63629-1219; 65862-133; 68071-3443; 68071-4963; 68071-5211; 69315-155; 70518-0335; 70518-2540; 70934-916; 71335-1451; 72789-176; 72789-296; 0591-0347; 55488-0300; 42708-028; 50090-6157; 51407-332; 58118-0123; 60687-593; 60687-683; 60760-499; 62135-449; 63187-441; 63629-7782; 63629-8992; 68071-3238; 68071-5284; 68788-8378; 68788-8928; 70934-789; 70934-930; 71205-090; 71205-161; 71610-015; 71610-276; 71610-697; 76282-155; 65862-323; 42708-086; 42708-164; 50090-0724; 53002-4972; 61919-293; 62332-070; 0527-1413; 70518-2629; 71205-793; 71335-0145; 71335-0652; 71335-1481; 71335-9647; 61919-580; 61919-695; 63629-1220; 67296-1487; 67296-1508; 68645-510; 68788-8417; 69584-362; 70518-1676; 71610-261; 72189-263; 57451-1127; 16729-182; 29300-128; 29300-129; 43353-240; 43353-719; 43547-398; 50090-5672; 50090-6156; 51655-088; 51655-502; 51655-616; 0228-2820; 63629-1218; 63629-8991; 68788-6844; 68788-8126; 69584-361; 70518-1728; 70518-2550; 70518-2666; 70934-170; 71335-0770; 0615-8449; 72789-303; 11722-060; 42419-001; 65862-134; 43063-747; 50268-404; 51655-522; 55700-006; 60760-430; 63187-440; 68071-2654; 68071-5266; 69315-130; 70518-3633; 70518-3749; 71205-589; 71205-980; 71335-0269; 12658-0405; 49452-3575; 23155-009; 35356-807; 43063-755; 50090-2744; 50090-6372; 63187-074; 63629-1121; 67296-2043; 67544-739; 68071-5273; 68788-7683; 70518-1595; 71335-1350; 71610-139; 71610-500; 0615-8450; 51927-0172; 51927-1611; 57451-1143; 16729-184; 23155-008; 23155-764; 43547-397; 50090-2727; 50090-5333; 50090-6532; 50228-111; 59746-382; 60760-199; 67296-1274; 68071-2159; 68788-7790; 69315-131; 69367-219; 0527-1414; 70518-0597; 70934-883; 71205-419; 71205-751; 71335-1713; 71610-014; 71610-471; 0615-8149; 12658-0605; 29300-130; 42708-027; 43353-717; 0172-2083; 50090-2706; 51655-674; 53002-1702; 53808-1111; 60760-315; 63187-367; 63187-548; 63629-8498; 68071-2607; 70934-074; 0615-7974; 12828-0008; 62512-0028; 43063-933; 50228-146; 51407-330; 51655-422; 51655-515; 51655-831; 63187-553; 67296-1174; 70518-0210; 70518-1486; 71335-0067; 71335-1976; 71610-488; 76282-154; 12658-0538; 16729-183; 46708-438; 50090-2171; 50228-112; 51407-331
UNII 0J48LPH2TH
Synonyms Hydrochlorothiazide | HCTZ | Dichlothiazide | Dihydrochlorothiazide | HydroDIURIL | Oretic | Sectrazide | Esidrix | Esidrex | Hypothiazide
Chemical Information
Molecular Formula C7H8ClN3O4S2
CAS Registry Number 58-93-5
SMILES C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anxiety disorder19.06.01.002--Not Available
Cognitive disorder19.21.02.001; 17.03.03.003--
Metabolic disorder14.11.01.0010.000010%Not Available
Pulseless electrical activity02.03.04.0200.000051%Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Inflammation10.02.01.089; 08.01.05.0070.000086%Not Available
Therapeutic reaction time decreased08.06.01.015--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.0010.000015%
Ill-defined disorder08.01.03.049--Not Available
Diverticular perforation07.04.04.0080.000010%Not Available
Obstructive airways disorder22.03.01.011--Not Available
Lymphocytic infiltration01.02.01.0120.000025%Not Available
Renal impairment20.01.03.010--Not Available
Sinus disorder22.04.06.002--
Neutropenic colitis07.08.01.014; 01.02.03.0100.000015%Not Available
Hypophagia19.09.01.004; 14.03.01.006; 07.01.06.0100.000068%Not Available
Choroidal effusion06.09.01.0080.000035%Not Available
Lichenoid keratosis23.01.01.0040.000048%Not Available
Chronic kidney disease20.01.03.0170.000025%
Mixed liver injury09.01.07.0150.000010%Not Available
Myocardial depression02.04.02.0150.000010%Not Available
Acute kidney injury20.01.03.0160.000225%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000040%Not Available
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 23.03.05.005; 10.01.01.0210.000020%Not Available
Mouth swelling07.05.04.007; 23.04.01.020; 10.01.05.020--Not Available
Sinus node dysfunction02.03.03.0170.000010%
Multiple organ dysfunction syndrome08.01.03.0570.000035%
Coeliac disease14.02.01.007; 10.04.04.012; 07.17.01.0080.000055%Not Available
Hyponatraemic syndrome14.05.04.0090.000025%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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