Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Guanfacine
Drug ID BADD_D01046
Description Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension[L11274] but is now indicated as an extended release tablet for the treatment of ADHD.[L11277] Guanfacine was first described in the literature in 1974.[A189841] Guanfacine was granted FDA approval on 27 October 1986.[L11274]
Indications and Usage For use alone or in combination with other classes of antihypertensive agents in the management of hypertension. Has also been used for the treatment of attention deficit hyperactivity disorder (ADHD) in pediatric patients.
Marketing Status Prescription; Discontinued
ATC Code C02AC02
DrugBank ID DB01018
KEGG ID D08031
MeSH ID D016316
PubChem ID 3519
TTD Drug ID Not Available
NDC Product Code 63304-927; 0591-0453; 63629-8203; 50090-4119; 70518-2771; 63304-924; 42291-326; 54092-519; 60429-961; 70518-1371; 0591-0444; 63304-925; 70518-0793; 54092-520; 63187-302; 60505-3927; 60429-960; 24979-536; 60429-963; 24658-731; 54092-517; 71205-945; 54092-515; 60429-962; 42806-048; 16714-193; 16714-190; 63629-1105; 42291-324; 42806-296; 24658-730; 63629-8161; 0228-2850; 42291-327; 24979-538; 16714-192; 63304-926; 0228-2853; 60505-3930; 16714-191; 60505-3928; 68094-019; 0228-2855; 50268-374; 24979-534; 65162-711; 0904-7140; 42291-325; 65162-713; 60505-3929; 71205-946; 70518-1369; 63629-7138; 24979-533; 71205-947; 54092-513; 0228-2851; 71205-944
Synonyms Guanfacine | Tenex | Guanfacine Hydrochloride | Hydrochloride, Guanfacine | Guanfacine Monohydrochloride | Monohydrochloride, Guanfacine | Lon798 | BS-100-141 | BS 100 141 | BS100141 | Estulic
Chemical Information
Molecular Formula C9H9Cl2N3O
CAS Registry Number 29110-47-2
SMILES C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abulia19.01.02.009; 17.02.05.0400.000699%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.0010.001399%Not Available
Hepatic enzyme increased13.03.01.0190.000699%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.001399%
Erectile dysfunction21.03.01.007; 19.08.04.001--
Ill-defined disorder08.01.03.049--Not Available
Cardiac fibrillation02.03.02.021--Not Available
Drug intolerance08.06.01.0130.000699%Not Available
Psychotic disorder19.03.01.0020.000699%
Autism spectrum disorder19.22.02.0020.000699%Not Available
Lichenoid keratosis23.01.01.0040.000699%Not Available
Treatment failure08.06.01.0170.000182%Not Available
Acute kidney injury20.01.03.016--
Impulsive behaviour19.18.01.0010.000699%Not Available
Regressive behaviour19.01.01.0040.000699%Not Available
Hypertensive emergency24.08.01.0040.000699%Not Available
Disturbance in social behaviour19.05.01.0180.002098%Not Available
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