Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Goserelin
Drug ID BADD_D01038
Description Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.
Indications and Usage Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty.
Marketing Status Prescription
ATC Code L02AE03
DrugBank ID DB00014
KEGG ID D04405
MeSH ID D017273
PubChem ID 5311128
TTD Drug ID D00BCG
NDC Product Code 70720-951; 55463-0005; 70720-950
Synonyms Goserelin | ICI-118630 | ICI 118630 | ICI118630 | Zoladex | Goserelin Acetate | Acetate, Goserelin
Chemical Information
Molecular Formula C59H84N18O14
CAS Registry Number 65807-02-5
SMILES CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C( CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C 6CCC(=O)N6
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fracture15.08.02.001; 12.04.02.001--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gastric cancer16.13.03.001; 07.21.02.0010.000384%Not Available
Gastrointestinal pain07.01.05.005--
Glucose tolerance impaired14.06.02.001; 05.06.02.001--
Gout14.09.01.001; 15.01.06.001--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Blood urine present13.13.02.0020.002206%Not Available
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.0030.002942%Not Available
Hair disorder23.02.06.003--Not Available
Hallucination, auditory19.10.02.0030.001471%Not Available
Headache17.14.01.001--
Heart rate increased13.14.04.0020.002206%Not Available
Hepatic function abnormal09.01.02.0010.001471%Not Available
Hepatitis09.01.07.004--Not Available
Hernia08.01.04.0010.001471%Not Available
Herpes simplex23.09.03.001; 11.05.02.001--Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
High density lipoprotein decreased13.12.01.003--Not Available
Hirsutism05.05.01.005; 23.02.04.001--
Hostility19.05.01.0030.001471%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
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