| Drug Name |
Glyburide |
| Drug ID |
BADD_D01030 |
| Description |
Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II.[L8123] It is typically given to patients who cannot be managed with the standard first line therapy, [metformin].[L8123] Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and calcium ion concentrations.[A183617]
Glyburide was granted FDA approval on 1 May 1984.[L8117] A formulation with metformin was granted FDA approval on on 31 July 2000.[L8120] |
| Indications and Usage |
Indicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
A10BB01 |
| DrugBank ID |
DB01016
|
| KEGG ID |
D00336
|
| MeSH ID |
D005905
|
| PubChem ID |
3488
|
| TTD Drug ID |
D05LYX
|
| NDC Product Code |
63187-667; 75834-204; 68071-5215; 63629-1393; 66267-103; 70934-855; 70934-409; 52817-121; 75834-203; 65862-318; 68382-656; 71209-009; 70934-715; 0093-9477; 0093-8344; 65862-029; 0121-0930; 0009-0352; 68382-657; 12579-056; 50090-3429; 0143-9920; 72241-040; 55289-606; 70518-1513; 0121-0931; 76333-155; 23155-056; 0115-1744; 53002-4170; 68382-658; 63629-2907; 65841-833; 12579-054; 68071-2589; 46438-0059; 68071-4142; 61919-330; 68071-4730; 0093-8343; 0009-3449; 65862-030; 68788-7970; 71335-0150; 42291-317; 0143-9918; 76333-154; 68071-2402; 63187-848; 50090-0495; 0143-9919; 55700-725; 0115-1742; 0093-8036; 72241-039; 0093-8035; 72241-038; 68071-5217; 0093-8342; 49452-3355; 23155-057; 52817-120; 71209-011; 70518-2695; 42291-316; 0121-0929; 65841-834; 43063-433; 70518-1646; 0093-9433; 68071-4695; 70934-569; 52817-122; 65862-028; 62147-0002; 63187-659; 50090-0494; 68071-5029; 68071-5030; 0093-8034; 50090-4215; 12828-0066; 71209-010; 61919-378; 0115-1743; 0093-9364; 50090-5776; 65841-832; 76333-156; 71335-0069; 70518-2644; 70518-1201; 12579-055; 43353-656; 75834-202; 43353-659; 0009-0341; 23155-058; 65691-0041 |
| Synonyms |
Glyburide | Glybenclamide | Glibenclamide | Diabeta | Euglucon 5 | Neogluconin | HB-419 | HB 419 | HB419 | HB-420 | HB 420 | HB420 | Maninil | Micronase | Daonil | Euglucon N |
