| Drug Name |
Gentamicin sulfate |
| Drug ID |
BADD_D01017 |
| Description |
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963.[A234349] It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams.[A234364] This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364]
Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity which may limit its use.[A234369] |
| Indications and Usage |
For treatment of serious infections caused by susceptible strains of the following microorganisms: P. aeruginosa, Proteus species (indole-positive and indole-negative), E. coli, Klebsiella-Enterobactor-Serratia species, Citrobacter species and Staphylococcus species (coagulase-positive and coagulase-negative). |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
D06AX07; J01GB03; S01AA11; S02AA14; S03AA06 |
| DrugBank ID |
DB00798
|
| KEGG ID |
D01063
|
| MeSH ID |
D005839
|
| PubChem ID |
44134730
|
| TTD Drug ID |
D0L9UU
|
| NDC Product Code |
63187-163; 63187-560; 71205-333; 61919-106; 67630-0003; 0338-0507; 76420-137; 68788-7336; 17478-827; 52565-090; 0713-0682; 63187-764; 52584-010; 0338-0503; 53002-9291; 63187-873; 0713-0683; 48866-8256; 63323-010; 0395-8229; 0404-9866; 61314-633; 60592-301; 17478-284; 0409-1207; 71205-560; 52584-207; 38779-0632; 71872-7216; 51552-0775; 53002-9290; 17478-826; 24208-580; 50090-2333; 17478-283; 42513-0008; 68071-1513; 0404-9865; 45802-056; 68071-4827; 66267-971; 68071-4775; 61919-918; 60758-188; 55154-2392; 45865-672; 0338-0505; 0338-0511; 51927-1610; 13985-603; 45802-046; 70518-1323; 62991-1072; 0338-0509; 50090-4770; 53002-9292 |
| Synonyms |
Gentamicins | Gentamycins | Garamycin | Gentacycol | Gentamicin Sulfate | Sulfate, Gentamicin | Gentamicin Sulfate (USP) | Gentavet | Genticin | G-Myticin | G Myticin | GMyticin | Gentamicin | Gentamycin |
