Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gadobenate dimeglumine
Drug ID BADD_D00983
Description Gadobenic acid (in the form of gadobenate dimeglumine) is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for visualizing the CNS and heart. In contrast to conventional extracellular fluid contrast agents, gadobenate dimeglumine is characterized by a weak and transient binding capacity to serum proteins. This binding leads to an increased relaxivity of gadobenate dimeglumine and, consequently, to a considerably increased signal intensity over that of other agents.
Indications and Usage Gadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues.
Marketing Status Prescription
ATC Code V08CA08
DrugBank ID DB00743
KEGG ID D04283
MeSH ID C064572
PubChem ID 105125
TTD Drug ID D01OIL
NDC Product Code 0270-5264; 57876-333; 0270-5164
Synonyms gadobenic acid | 3,6,9-triaza-12-oxa-3,6,9-tricarboxymethylene-10-carboxy-13-phenyltridecanoic acid, gadolinium | Gd-BOPTA | gadobenic acid, dimeglumine salt | gadobenate dimeglumine | gadolinium-BOPTA-Dimeg | MultiHance | Gd(BOPTA)2 | B 19036 | B-19036 | gadolinium-benzyloxypropionyl tetraacetate
Chemical Information
Molecular Formula C22H31N3O11
CAS Registry Number 113786-33-7
SMILES C1=CC=C(C=C1)COCC(C(=O)O)N(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pulse pressure decreased13.14.04.008--Not Available
Pyrexia08.05.02.003--
Rales22.02.04.004--Not Available
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.003--Not Available
Rash macular23.03.13.003--Not Available
Rash maculo-papular23.03.13.004--
Red blood cell count decreased13.01.05.007--Not Available
Renal failure20.01.03.005--Not Available
Respiratory disorder22.02.07.002--Not Available
Respiratory failure14.01.04.003; 22.02.06.002--
Rhinitis22.07.03.006; 11.01.13.004--
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.001--
Sensory disturbance17.02.07.006--Not Available
Serum ferritin13.11.01.045--Not Available
Shock24.06.02.002--Not Available
Sinus bradycardia02.03.03.009--
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stupor19.02.05.004; 17.02.04.007--Not Available
Supraventricular extrasystoles02.03.03.011--Not Available
Swelling08.01.03.015--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Thrombocytosis01.08.02.001--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue disorder07.14.01.002--Not Available
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