Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Furosemide
Drug ID BADD_D00979
Description Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.[L7958] Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.[L7961] It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.[A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.[L7958]
Indications and Usage For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Marketing Status Prescription; Discontinued
ATC Code C03CA01
DrugBank ID DB00695
KEGG ID D00331
MeSH ID D005665
PubChem ID 3440
TTD Drug ID D0PQ3G
NDC Product Code 43353-018; 12634-416; 68083-432; 30698-066; 51662-1226; 61919-242; 0404-9864; 68071-3273; 0054-3298; 68071-4349; 66432-550; 55154-5539; 0404-9863; 0615-7938; 68788-6948; 0054-8301; 60760-708; 0904-7177; 43063-702; 70193-0002; 0378-0216; 30698-067; 0615-7937; 63187-097; 0054-4299; 71288-203; 57451-0006; 71335-0129; 70121-1164; 0615-8368; 42708-123; 51927-1784; 36000-283; 16729-500; 51407-115; 52584-052; 0054-4297; 68083-433; 63323-280; 71052-238; 70121-1163; 68083-434; 43353-341; 71872-7278; 0409-9631; 48087-0054; 52584-283; 25021-311; 66432-549; 55154-5540; 71610-096; 72789-032; 70121-1076; 36000-065; 0054-4301; 68071-4022; 55154-2365; 0904-7178; 0054-8299; 70529-550; 49452-3222; 63187-437; 70518-3061; 36000-282; 58118-0143; 50090-5702; 68071-4445; 42291-468; 0404-9861; 57451-0007; 63187-517; 55154-9582; 43063-716; 0615-8369; 51662-1336; 71610-635; 63629-1215; 71872-7277; 63629-8057; 51662-1575; 68071-1708; 12634-533; 50090-5706; 0378-0232; 53002-4300; 71335-1683; 0054-8297; 23155-473; 68071-2461; 68788-7354; 0409-6102; 42291-470; 71872-7059; 63629-1119; 70518-0836; 17337-0087; 60432-613; 70934-111; 43547-401; 42291-469; 72789-033; 71335-0384; 51662-1227; 68094-756; 70518-0050; 71335-0601; 68071-2360; 55700-461; 72789-157; 55150-323; 63629-1216; 55154-2364; 51927-0078; 68071-1809; 70518-2766; 63629-1217; 67296-1665; 60760-707; 68071-4522; 71335-0842; 0409-1639; 53808-1109; 51662-1572; 71610-634; 70860-302; 43353-220; 50090-5429; 71610-284; 82348-105; 70518-0251; 71610-049; 50090-3455; 43353-221; 69315-116; 36000-063; 50090-2951; 0615-8370; 72789-030; 63629-1214; 55150-322; 63629-1120; 71610-309; 55154-4452; 63187-790; 70518-0809; 71335-0397; 43063-849; 0378-0208; 43353-747; 50090-3313; 51927-0077; 71610-636; 71872-7127; 68071-4534; 51407-114; 36000-284; 63187-506; 61919-442; 63629-1435; 50090-2713; 50090-4111; 68788-7265; 51552-0940; 30698-060; 68071-2325; 43063-806; 68071-2313; 51662-1574; 66326-401; 43547-402; 71872-7236; 50090-4109; 63187-739; 36000-064; 16729-501; 48087-0053; 16729-502; 51079-073; 50090-3338; 0404-9862; 71335-1632; 50090-0150; 50090-3488; 64679-759; 51407-113; 70529-062; 51079-072; 43547-403; 52584-322; 0054-3294; 68094-867; 81565-201; 63415-0025; 55700-452; 71610-305; 72166-003; 60760-217; 51079-527; 55154-9581; 70529-061; 43353-069; 71610-308; 0615-7957; 55150-324; 68788-6784; 67296-1547; 50090-2560; 67296-0691; 50090-3339; 63629-8058; 71335-0852; 69315-118; 52584-284; 69315-117; 68071-3194; 70529-549
Synonyms Furosemide | Frusemide | Fursemide | Frusemid | Fusid | Lasix | Furosemide Monohydrochloride | Errolon | Furanthril | Furantral | Furosemide Monosodium Salt
Chemical Information
Molecular Formula C12H11ClN2O5S
CAS Registry Number 54-31-9
SMILES C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperparathyroidismParathyroid hormone/parathyroid hormone-related peptide receptorQ03431T677106637931; 2809941
Renal failureVery low-density lipoprotein receptorP98155Not Available6624545; 190608; 227218; 8740580; 189577; 211802; 6941788; 6586074; 8139482
Renal failureLipoprotein lipaseP06858T286926624545; 190608; 227218; 8740580; 189577; 211802; 6941788; 6586074; 8139482
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Epilepsy17.12.03.002--Not Available
Epistaxis22.04.03.001; 24.07.01.0050.000602%
Erythema23.03.06.0010.000856%Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.000063%
Extrasystoles02.03.02.0030.000063%Not Available
Eye disorder06.08.03.001--Not Available
Eye swelling06.08.03.003--Not Available
Face oedema10.01.05.002; 08.01.07.003; 23.04.01.0040.000127%
Facial bones fracture15.08.04.001; 12.04.05.0020.000063%Not Available
Faeces discoloured07.01.03.0020.000095%Not Available
Fatigue08.01.01.002--
Fear19.06.03.001--Not Available
Febrile neutropenia01.02.03.002; 08.05.02.004--
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.0080.000063%Not Available
Feeling hot08.01.09.009--Not Available
Femur fracture15.08.03.003; 12.04.01.003--Not Available
Flank pain15.03.04.003; 20.02.03.006; 08.01.08.0070.000063%
Flat affect19.04.01.004--Not Available
Flatulence07.01.04.002--
Fluid overload02.05.04.004; 14.05.06.0010.000349%Not Available
Fluid retention20.01.02.003; 14.05.06.0020.000539%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Food poisoning12.03.01.024; 11.07.02.001; 07.11.01.0070.000095%Not Available
Gait disturbance17.02.05.016; 08.01.02.0020.000570%
Gamma-glutamyltransferase increased13.03.01.0110.000190%
Gastric haemorrhage24.07.02.007; 07.12.01.0010.000095%
Gastric polyps07.20.01.003; 16.05.03.0010.000063%Not Available
Gastric ulcer07.04.03.0020.000190%
Gastric ulcer haemorrhage24.07.02.003; 07.04.03.0050.000158%Not Available
The 8th Page    First    Pre   8 9 10 11 12    Next   Last    Total 25 Pages