Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Furosemide
Drug ID BADD_D00979
Description Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.[L7958] Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.[L7961] It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.[A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.[L7958]
Indications and Usage For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Marketing Status Prescription; Discontinued
ATC Code C03CA01
DrugBank ID DB00695
KEGG ID D00331
MeSH ID D005665
PubChem ID 3440
TTD Drug ID D0PQ3G
NDC Product Code 43353-018; 12634-416; 68083-432; 30698-066; 51662-1226; 61919-242; 0404-9864; 68071-3273; 0054-3298; 68071-4349; 66432-550; 55154-5539; 0404-9863; 0615-7938; 68788-6948; 0054-8301; 60760-708; 0904-7177; 43063-702; 70193-0002; 0378-0216; 30698-067; 0615-7937; 63187-097; 0054-4299; 71288-203; 57451-0006; 71335-0129; 70121-1164; 0615-8368; 42708-123; 51927-1784; 36000-283; 16729-500; 51407-115; 52584-052; 0054-4297; 68083-433; 63323-280; 71052-238; 70121-1163; 68083-434; 43353-341; 71872-7278; 0409-9631; 48087-0054; 52584-283; 25021-311; 66432-549; 55154-5540; 71610-096; 72789-032; 70121-1076; 36000-065; 0054-4301; 68071-4022; 55154-2365; 0904-7178; 0054-8299; 70529-550; 49452-3222; 63187-437; 70518-3061; 36000-282; 58118-0143; 50090-5702; 68071-4445; 42291-468; 0404-9861; 57451-0007; 63187-517; 55154-9582; 43063-716; 0615-8369; 51662-1336; 71610-635; 63629-1215; 71872-7277; 63629-8057; 51662-1575; 68071-1708; 12634-533; 50090-5706; 0378-0232; 53002-4300; 71335-1683; 0054-8297; 23155-473; 68071-2461; 68788-7354; 0409-6102; 42291-470; 71872-7059; 63629-1119; 70518-0836; 17337-0087; 60432-613; 70934-111; 43547-401; 42291-469; 72789-033; 71335-0384; 51662-1227; 68094-756; 70518-0050; 71335-0601; 68071-2360; 55700-461; 72789-157; 55150-323; 63629-1216; 55154-2364; 51927-0078; 68071-1809; 70518-2766; 63629-1217; 67296-1665; 60760-707; 68071-4522; 71335-0842; 0409-1639; 53808-1109; 51662-1572; 71610-634; 70860-302; 43353-220; 50090-5429; 71610-284; 82348-105; 70518-0251; 71610-049; 50090-3455; 43353-221; 69315-116; 36000-063; 50090-2951; 0615-8370; 72789-030; 63629-1214; 55150-322; 63629-1120; 71610-309; 55154-4452; 63187-790; 70518-0809; 71335-0397; 43063-849; 0378-0208; 43353-747; 50090-3313; 51927-0077; 71610-636; 71872-7127; 68071-4534; 51407-114; 36000-284; 63187-506; 61919-442; 63629-1435; 50090-2713; 50090-4111; 68788-7265; 51552-0940; 30698-060; 68071-2325; 43063-806; 68071-2313; 51662-1574; 66326-401; 43547-402; 71872-7236; 50090-4109; 63187-739; 36000-064; 16729-501; 48087-0053; 16729-502; 51079-073; 50090-3338; 0404-9862; 71335-1632; 50090-0150; 50090-3488; 64679-759; 51407-113; 70529-062; 51079-072; 43547-403; 52584-322; 0054-3294; 68094-867; 81565-201; 63415-0025; 55700-452; 71610-305; 72166-003; 60760-217; 51079-527; 55154-9581; 70529-061; 43353-069; 71610-308; 0615-7957; 55150-324; 68788-6784; 67296-1547; 50090-2560; 67296-0691; 50090-3339; 63629-8058; 71335-0852; 69315-118; 52584-284; 69315-117; 68071-3194; 70529-549
Synonyms Furosemide | Frusemide | Fursemide | Frusemid | Fusid | Lasix | Furosemide Monohydrochloride | Errolon | Furanthril | Furantral | Furosemide Monosodium Salt
Chemical Information
Molecular Formula C12H11ClN2O5S
CAS Registry Number 54-31-9
SMILES C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperparathyroidismParathyroid hormone/parathyroid hormone-related peptide receptorQ03431T677106637931; 2809941
Renal failureLipoprotein lipaseP06858T286926624545; 190608; 227218; 8740580; 189577; 211802; 6941788; 6586074; 8139482
Renal failureVery low-density lipoprotein receptorP98155Not Available6624545; 190608; 227218; 8740580; 189577; 211802; 6941788; 6586074; 8139482
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood albumin decreased13.09.01.0010.000222%Not Available
Blood bicarbonate decreased13.11.01.0190.000017%
Blood bicarbonate increased13.11.01.0010.000063%Not Available
Blood bilirubin increased13.03.01.0080.000190%
Blood calcium decreased13.11.01.0020.000190%Not Available
Blood chloride decreased13.11.01.0040.000095%Not Available
Blood chloride increased13.11.01.0050.000095%Not Available
Blood cholesterol increased13.12.01.002--
Blood creatine increased13.13.01.0010.000127%Not Available
Blood creatine phosphokinase increased13.04.01.0010.000570%
Blood creatinine increased13.13.01.0040.001648%
Blood glucose abnormal13.02.02.0080.000063%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.000222%
Blood lactic acid increased13.02.01.0150.000127%Not Available
Blood parathyroid hormone increased13.10.07.0020.000158%Not Available
Blood potassium decreased13.11.01.0100.000729%Not Available
Blood potassium increased13.11.01.0110.000380%Not Available
Blood pressure decreased13.14.03.0020.000761%Not Available
Blood pressure diastolic decreased13.14.03.0030.000095%Not Available
Blood pressure increased13.14.03.0050.000602%Not Available
Blood pressure systolic decreased13.14.03.0070.000095%Not Available
Blood pressure systolic increased13.14.03.0060.000063%Not Available
Blood sodium decreased13.11.01.0120.000254%Not Available
Blood sodium increased13.11.01.0130.000095%Not Available
Blood triglycerides increased13.12.03.001--Not Available
Blood urea increased13.13.01.0060.000792%Not Available
Blood uric acid increased13.02.04.0010.000222%Not Available
Body temperature decreased13.15.01.0100.000127%Not Available
Body temperature increased13.15.01.0010.000095%Not Available
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