Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fosaprepitant
Drug ID BADD_D00962
Description Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Indications and Usage For the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
Marketing Status Prescription; Discontinued
ATC Code A04AD12
DrugBank ID DB06717
KEGG ID D10895
MeSH ID C579707
PubChem ID 135413538
TTD Drug ID Not Available
NDC Product Code 71288-418; 67457-888; 71839-104; 16714-120; 43598-948; 70625-311; 68180-690; 72205-083; 69539-181; 63323-972; 72205-026; 60505-6105; 16714-929; 43598-859; 69097-830; 67457-889; 72603-106; 70710-1615; 68001-421; 16729-240; 72205-054; 68001-517; 0591-4385; 0781-3497; 69539-034
Synonyms fosaprepitant | Emend for injection | fosaprepitant dimeglumine | L 785,298 | L785,298 | L-785,298
Chemical Information
Molecular Formula C23H22F7N4O6P
CAS Registry Number 172673-20-0
SMILES CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C( C=C4)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoaesthesia17.02.06.023--Not Available
Hyponatraemia14.05.04.002--
Hypotension24.06.03.0020.000561%
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
Miosis17.02.11.002; 06.05.03.003--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Nausea07.01.07.0010.000935%
Nervous system disorder17.02.10.001--Not Available
Neutrophil count decreased13.01.06.010--
Oedema08.01.07.006; 14.05.06.010--Not Available
Osteoarthritis15.01.04.001--Not Available
Oxygen saturation decreased13.02.01.0040.000561%Not Available
Pain08.01.08.0040.000374%
Palpitations02.01.02.003--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Polydipsia14.05.02.001; 05.03.03.002--Not Available
Prurigo23.03.04.017--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
Seizure17.12.03.0010.000561%
Sensory disturbance17.02.07.006--Not Available
Skin disorder23.03.03.007--Not Available
The 3th Page    First    Pre   3 4 5    Next   Last    Total 5 Pages