Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fosaprepitant
Drug ID BADD_D00962
Description Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Indications and Usage For the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
Marketing Status Prescription; Discontinued
ATC Code A04AD12
DrugBank ID DB06717
KEGG ID D10895
MeSH ID C579707
PubChem ID 135413538
TTD Drug ID Not Available
NDC Product Code 71288-418; 67457-888; 71839-104; 16714-120; 43598-948; 70625-311; 68180-690; 72205-083; 69539-181; 63323-972; 72205-026; 60505-6105; 16714-929; 43598-859; 69097-830; 67457-889; 72603-106; 70710-1615; 68001-421; 16729-240; 72205-054; 68001-517; 0591-4385; 0781-3497; 69539-034
Synonyms fosaprepitant | Emend for injection | fosaprepitant dimeglumine | L 785,298 | L785,298 | L-785,298
Chemical Information
Molecular Formula C23H22F7N4O6P
CAS Registry Number 172673-20-0
SMILES CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C( C=C4)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.0040.002432%
Dysuria20.02.02.002--
Ear disorder04.03.01.001--Not Available
Eructation07.01.02.003--
Erythema23.03.06.0010.001310%Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Euphoric mood19.04.02.006--
Eye disorder06.08.03.001--Not Available
Faeces hard07.01.03.003--Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.0090.000561%Not Available
Flatulence07.01.04.002--
Flushing08.01.03.025; 24.03.01.002; 23.06.05.0030.002619%
Gait disturbance08.01.02.002; 17.02.05.016--
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Glycosuria20.02.01.005--
Haematuria20.02.01.006; 24.07.01.047--
Blood urine present13.13.02.002--Not Available
Headache17.14.01.001--
Hiccups22.02.04.002; 07.01.06.009--
Hyperhidrosis23.02.03.004; 08.01.03.0280.000561%
Hypersensitivity10.01.03.0030.000561%
Hypertension24.08.02.0010.000374%
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