Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluticasone propionate
Drug ID BADD_D00947
Description Fluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].
Indications and Usage Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
Marketing Status Prescription; OTC; Discontinued
ATC Code D07AC17; R01AD08; R03BA05
DrugBank ID DB00588
KEGG ID D01708
MeSH ID D000068298
PubChem ID 444036
TTD Drug ID D0LC6K
NDC Product Code 70518-1655; 65089-0033; 53943-006; 68071-4156; 15308-0200; 46122-338; 37808-205; 0363-0881; 11673-262; 60505-0847; 21130-122; 53002-1294; 63868-656; 50383-968; 50909-5175; 50090-0968; 0363-0652; 0173-0600; 70518-2930; 21130-680; 0363-5010; 63654-380; 55301-506; 41520-703; 21130-089; 50594-319; 41250-634; 68788-6926; 41250-933; 63629-8659; 71143-375; 50090-1978; 60505-0829; 50090-2267; 56062-107; 0173-0718; 11822-0901; 53873-079; 60505-6134; 0113-0285; 72559-002; 36800-222; 68196-208; 49035-362; 22552-0043; 80267-000; 0173-0719; 50090-0916; 69842-900; 69842-765; 38779-2760; 49348-182; 81522-005; 59310-200; 11673-220; 71205-443; 64918-1600; 41163-023; 0173-0602; 60505-0955; 30142-301; 55910-773; 68016-723; 64918-1118; 61919-930; 64525-8000; 63190-0520; 55700-714; 30142-258; 68196-210; 46122-684; 0713-0631; 50090-4410; 64918-1700; 59310-311; 60505-6167; 30142-767; 69256-061; 50090-2880; 50383-700; 0363-0024; 63629-8661; 53104-7531; 70518-1223; 68788-9678; 81522-002; 63868-400; 55700-680; 45802-222; 0135-0582; 53002-7692; 68391-133; 64525-6560; 53943-500; 50090-0934; 50090-2557; 60505-6205; 45802-221; 11822-7005; 45802-441; 63187-021; 49035-060; 55315-800; 68462-427; 64024-007; 62011-0269; 58175-0361; 37835-997; 53002-1310; 0713-0729; 72189-004; 11822-1177; 63940-501; 52482-001; 59310-525; 41520-553; 11822-5000; 63981-001; 60429-195; 50090-3513; 0173-0601; 72288-333; 63379-001; 49035-200; 68071-2582; 0168-0434; 50090-0910; 68788-7788; 11673-388; 69842-770; 68998-600; 46122-386; 63187-638; 63629-8662; 11822-7003; 36800-572; 16812-005; 59310-505; 0173-0720; 11673-103; 0536-1183; 37808-340; 55319-019; 49076-5501; 60505-6201; 10337-434; 63629-8660; 63187-959; 53002-7691; 52221-106; 55315-825; 68071-4868; 63187-957; 36800-128; 50090-1245; 0168-0332; 51672-4095; 11822-5001; 0113-7117; 72288-119; 59310-515; 53873-078; 0054-3270; 55910-607; 69842-757; 50090-3679; 49035-063; 68071-1638; 80159-201; 0113-0028; 68788-7658; 63629-8658; 69168-380; 55018-301; 63187-806; 50090-1187; 70000-0110; 0363-5012; 76420-106; 0135-0576; 60432-264; 41163-100; 59310-114; 0713-0632; 53002-7690; 69842-228; 79903-071; 68788-9925; 63629-8663; 51927-0013; 69306-016; 50090-3803; 50090-2484; 51552-1310; 76162-656
Synonyms Fluticasone | Flonase | Flovent HFA | HFA, Flovent | Cutivate | Fluticasone Propionate | Propionate, Fluticasone | Flixonase | Flixotide | Flovent
Chemical Information
Molecular Formula C25H31F3O5S
CAS Registry Number 80474-14-2
SMILES CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Insomnia19.02.01.002; 17.15.03.002--
Intestinal obstruction07.13.01.0020.000221%Not Available
Intracranial pressure increased17.07.02.0020.000332%Not Available
Intraocular pressure increased13.07.04.0020.000221%Not Available
Irritability19.04.02.013; 08.01.03.0110.000332%
Laceration23.03.11.004; 12.01.06.0060.000442%Not Available
Lacrimation increased06.08.02.0040.000221%
Leukoderma23.05.02.001--Not Available
Lip oedema23.04.01.006; 10.01.05.004; 07.05.04.0040.000332%Not Available
Lip swelling07.05.04.005; 23.04.01.007; 10.01.05.0050.000332%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.0020.000332%Not Available
Lung disorder22.02.07.0010.000332%Not Available
Malaise08.01.01.003--
Memory impairment19.20.01.003; 17.03.02.0030.000221%
Menopause26.03.01.001--Not Available
Menstruation delayed05.05.01.010; 21.01.02.0030.000221%Not Available
Migraine17.14.02.001; 24.03.05.0030.000221%Not Available
Miliaria23.02.03.014--Not Available
Mood swings19.04.03.0010.000221%Not Available
Multiple fractures15.08.02.005; 12.04.02.009--Not Available
Muscular weakness17.05.03.005; 15.05.06.0010.000221%
Myalgia15.05.02.0010.000442%
Nasal congestion22.04.04.0010.001217%
Nasal dryness22.04.03.002--Not Available
Nasal septum perforation22.04.03.003--Not Available
Nasal ulcer22.04.03.011--Not Available
Nasopharyngitis11.01.13.002; 22.07.03.0020.000885%Not Available
Nausea07.01.07.001--
Neck pain15.03.04.0090.000332%
Nervous system disorder17.02.10.001--Not Available
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