Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Flurbiprofen
Drug ID BADD_D00941
Description Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Indications and Usage Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.
Marketing Status approved; investigational
ATC Code M01AE09; M02AA19; R02AX01; S01BC04
DrugBank ID DB00712
KEGG ID D00330
MeSH ID D005480
PubChem ID 3394
TTD Drug ID D0A1PX
NDC Product Code 49452-3178; 71574-111; 22568-1093; 38779-2739; 51552-0818; 51927-0008; 55545-0405; 63629-8338; 0093-0711; 63629-8808; 51686-0004; 66577-029; 51927-0219; 62991-3064; 17511-123; 61891-001; 62756-510; 68788-7341; 63275-9913; 43063-992
UNII 5GRO578KLP
Synonyms Flurbiprofen | 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic Acid | Flubiprofen | Fluriproben | Dobrofen | E-7869 | E 7869 | E7869 | Nu-Flurbiprofen | Nu Flurbiprofen | Ocufen | ratio-Flurbiprofen | ratio Flurbiprofen | Strefen | Flugalin | Flurbiprofen Sodium | Froben | Neo Artrol | Novo-Flurprofen | Novo Flurprofen | Ansaid | Apo-Flurbiprofen | Apo Flurbiprofen | BTS-18322 | BTS 18322 | BTS18322 | Cebutid | Froben SR | Ocuflur
Chemical Information
Molecular Formula C15H13FO2
CAS Registry Number 5104-49-4
SMILES CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Premature delivery18.07.01.0060.002389%
Prostatic disorder21.04.01.001--Not Available
Proteinuria20.02.01.011--
Pruritus23.03.12.0010.003583%
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary infarction24.04.09.001; 22.06.02.002--Not Available
Purpura01.01.04.003; 24.07.06.005; 23.06.01.004--
Pyrexia08.05.02.0030.002389%
Pyuria20.08.02.016; 11.01.08.043--Not Available
Rash23.03.13.001--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Renal failure20.01.03.005--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Rhinorrhoea22.12.03.0210.003583%
Right ventricular failure02.05.03.002--Not Available
Scleritis10.02.01.025; 06.04.07.002--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin exfoliation23.03.07.003--Not Available
Skin ulcer24.04.03.007; 23.07.03.003--
Somnolence19.02.05.003; 17.02.04.0060.002389%
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.003--Not Available
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Stomatitis07.05.06.005--
Subarachnoid haemorrhage12.01.10.011; 24.07.04.004; 17.08.01.010--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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