Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluphenazine hydrochloride
Drug ID BADD_D00937
Description A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.
Indications and Usage For management of manifestations of psychotic disorders.
Marketing Status Discontinued; Prescription
ATC Code N05AB02
DrugBank ID DB00623
KEGG ID D00791
MeSH ID D005476
PubChem ID 67356
TTD Drug ID D0P5SA
NDC Product Code 0121-0653; 50090-5758; 10135-726; 16714-002; 69238-1680; 70710-1489; 0904-7157; 70518-3095; 16714-675; 0904-7159; 51407-458; 0527-1789; 16714-004; 10135-728; 70771-1582; 70954-275; 10135-725; 70710-1488; 0904-7160; 70518-3098; 0904-7158; 68084-950; 16714-005; 10135-727; 70771-1584; 0527-1788; 43598-036; 16714-674; 42291-437; 42291-436; 70954-274; 70518-3008; 68084-846; 70954-276; 43598-035; 70771-1581; 70518-1496; 69238-1678; 16714-003; 42291-438; 50268-369; 51407-461; 46708-937; 70710-1491; 43598-034; 68022-7063; 90096-122; 0527-1791; 70954-273; 42291-435; 16714-673; 0527-1790; 69766-068; 70710-1490; 69238-1681; 63323-281; 90096-124; 0121-0654; 51407-459; 90096-121; 51407-460; 70771-1583; 16714-672; 70518-3003; 48954-468; 69238-1679; 17856-0654; 90096-123; 46204-0002; 76055-0044; 50090-4740; 70518-0318; 43598-037
Synonyms Fluphenazine | Flufenazin | Fluphenazine Hydrochloride | Hydrochloride, Fluphenazine | Lyogen | Prolixin
Chemical Information
Molecular Formula C22H28Cl2F3N3OS
CAS Registry Number 146-56-5
SMILES C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(4) dopamine receptorP21917T24983Not Available
Tardive dyskinesiaD(2) dopamine receptorP14416T67162Not Available
Tardive dyskinesiaD(3) dopamine receptorP35462T02551Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukopenia01.02.02.001--Not Available
Libido increased21.03.02.007; 19.08.03.002--
Mastication disorder17.05.03.006; 15.03.01.009; 07.01.06.016--Not Available
Menstruation irregular21.01.01.005; 05.05.01.008--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Neurogenic bladder20.03.03.001; 17.10.01.002--Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.005--Not Available
Oculogyric crisis06.05.02.002; 17.01.03.002--Not Available
Oedema peripheral08.01.07.007; 14.05.06.011; 02.05.04.007--
Opisthotonus17.01.03.005--Not Available
Pancytopenia01.03.03.003--Not Available
Parkinsonism17.01.05.003--Not Available
Photosensitivity reaction23.03.09.003--
Polyuria20.02.03.002--Not Available
Pregnancy test false positive13.10.05.003--Not Available
Protrusion tongue17.02.05.037; 07.14.02.002--Not Available
Pruritus23.03.12.001--
Restlessness19.11.02.002; 17.02.05.021--
Salivary hypersecretion07.06.01.009--Not Available
Seborrhoea23.02.07.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Swelling08.01.03.015--Not Available
Systemic lupus erythematosus23.03.02.006; 15.06.02.003; 10.04.03.004--Not Available
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Brain oedema17.07.02.003; 12.01.10.010--
Analgesic therapy25.01.04.001--Not Available
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