Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fludarabine phosphate
Drug ID BADD_D00915
Description Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Indications and Usage For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Marketing Status Prescription; Discontinued
ATC Code L01BB05
DrugBank ID DB01073
KEGG ID D01907
MeSH ID C042382
PubChem ID 30751
TTD Drug ID D0TO2R
NDC Product Code 45963-621; 53183-7841; 59923-604; 51916-310; 33656-0015; 63323-192; 24201-237; 25021-242; 45963-609; 58623-0043; 59605-7136
Synonyms fludarabine phosphate | fludarabine 5'-monophosphate | 9 beta-D-arabinofuranosyl-2-fluoroadenine monophosphate | fludarabine monophosphate | FaraAMP | fluoro-ara-AMP | 9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)- | F-ara-AMP | NSC 312887 | NSC-312887 | Beneflur | Fludara
Chemical Information
Molecular Formula C10H13FN5O7P
CAS Registry Number 75607-67-9
SMILES C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Toxic epidermal necrolysis10.01.01.006; 23.03.01.008; 12.03.01.015; 11.07.01.006--
Transient ischaemic attack24.04.06.005; 17.08.04.001--
Tumour lysis syndrome16.32.03.002; 14.05.01.004--
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urinary hesitation20.02.02.009--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Mental status changes19.07.01.001--Not Available
Hypoacusis04.02.01.006--
Precancerous skin lesion23.01.06.004--Not Available
Deep vein thrombosis24.01.02.003--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Acquired haemophilia01.01.01.002--Not Available
Evans syndrome10.04.01.003; 01.06.01.002--Not Available
Haemorrhage24.07.01.002--Not Available
Skin toxicity23.03.03.032; 12.03.01.020--Not Available
Lymphoproliferative disorder16.21.02.001; 01.13.02.001--Not Available
Malnutrition14.03.02.004--Not Available
Optic nerve disorder17.04.05.004; 06.02.08.001--
Optic neuropathy06.02.08.002; 17.04.05.005--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Renal function test abnormal13.13.01.012--Not Available
Ill-defined disorder08.01.03.049--Not Available
Immunodeficiency10.03.02.002--Not Available
Pulmonary toxicity22.01.02.007; 12.03.01.013--Not Available
Bone marrow failure01.03.03.005--
Cytopenia01.03.03.012--Not Available
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