Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fludarabine
Drug ID BADD_D00914
Description Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Indications and Usage For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Marketing Status Not Available
ATC Code L01BB05
DrugBank ID DB01073
KEGG ID D07966
MeSH ID C024352
PubChem ID 657237
TTD Drug ID D0F2XQ
NDC Product Code Not Available
Synonyms fludarabine | 9H-purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- | F-ara-A | 2-fluoroadenine arabinoside | 9-beta-D-arabinofuranosyl-2-fluoroadenine
Chemical Information
Molecular Formula C10H12FN5O4
CAS Registry Number 21679-14-1
SMILES C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic function abnormal09.01.02.0010.000208%Not Available
Hepatitis09.01.07.0040.001066%Not Available
Herpes simplex11.05.02.001; 23.09.03.001--Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.001332%
Hodgkin's disease16.31.01.001; 01.16.01.0010.000208%Not Available
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hyperphosphataemia14.04.03.007--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hyperthermia12.05.01.002; 08.05.01.0010.000533%Not Available
Hyperuricaemia14.09.01.003--
Hypoaesthesia17.02.06.023--Not Available
Hypocalcaemia14.04.01.004--
Hypokalaemia14.05.03.0020.001066%
Hypomagnesaemia14.04.02.0010.000533%
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.0010.000533%
Hypoxia22.02.02.003--
Ileus07.13.01.0010.001598%
Infection11.01.08.0020.000347%Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Interstitial lung disease10.02.01.033; 22.01.02.0030.000139%Not Available
Kaposi's sarcoma16.33.02.001; 11.05.17.0010.000533%Not Available
Leukoencephalopathy17.13.02.0030.001865%
Leukopenia01.02.02.0010.000799%Not Available
Liver disorder09.01.08.0010.000139%Not Available
Liver function test abnormal13.03.01.013--Not Available
Lung disorder22.02.07.0010.000533%Not Available
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