Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluconazole
Drug ID BADD_D00912
Description Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.[A174325]
Indications and Usage For the treatment of fungal infections.
Marketing Status Prescription; Discontinued
ATC Code D01AC15; J02AC01
DrugBank ID DB00196
KEGG ID D00322
MeSH ID D015725
PubChem ID 3365
TTD Drug ID D09LNI
NDC Product Code 51407-424; 55111-144; 51407-301; 53104-7569; 70934-783; 70985-015; 16571-210; 68071-2557; 63187-584; 63275-9960; 68071-2347; 65862-059; 50090-0869; 51686-0006; 66039-857; 63629-8970; 67405-601; 70710-1137; 16714-691; 0395-8036; 55700-945; 51407-299; 51407-302; 55154-3400; 51407-300; 53002-4198; 65862-060; 51407-425; 57237-003; 50090-4426; 51407-426; 68071-4651; 62559-990; 68462-104; 0172-5412; 0172-5410; 72189-143; 63187-096; 0143-9668; 63629-1950; 16571-211; 50090-3899; 68071-4002; 43063-642; 68071-4501; 55289-148; 71335-1268; 71335-0686; 51672-4066; 52343-087; 68071-2436; 71205-563; 70771-1065; 52343-085; 51672-4065; 50090-4425; 0049-3410; 63629-1948; 0904-6500; 38779-2442; 71335-1037; 70710-1140; 50090-2195; 55111-145; 59762-5018; 68071-2609; 57237-149; 52343-086; 71205-081; 70985-016; 16571-212; 61919-380; 51927-3783; 0049-3450; 70518-0560; 62559-993; 25021-184; 52343-088; 72789-209; 72189-149; 76420-164; 50090-5299; 70710-1138; 60760-804; 16714-696; 70518-3312; 0143-9669; 70934-935; 16714-692; 50268-339; 65862-299; 51672-4067; 71335-1511; 63629-1947; 0049-3440; 0338-6045; 50090-3194; 68084-728; 64567-0002; 59762-5017; 67405-604; 70771-1063; 65862-300; 68071-2601; 49452-3149; 59762-5016; 65427-025; 59762-5015; 72189-140; 61919-419; 57237-006; 72789-096; 51552-1031; 67405-603; 55111-039; 0904-6501; 53069-0380; 71335-0557; 60760-803; 0338-6046; 50090-4864; 65015-601; 70985-013; 62559-992; 71335-1954; 59762-5029; 70710-1139; 16714-693; 0049-3420; 71335-0764; 68788-7959; 70518-2415; 71335-1175; 68001-253; 0143-9666; 51655-435; 63629-8971; 71335-1895; 53002-4400; 63629-9091; 53002-2198; 70518-2411; 62559-991; 55111-146; 71335-1448; 65841-108; 71205-573; 68001-252; 71205-104; 51672-4064; 72189-342; 43063-645; 51407-427; 16714-695; 59762-5030; 70934-501; 71335-1948; 68462-102; 63629-7986; 55111-143; 0172-5411; 60592-209; 57237-150; 70518-3092; 62991-2651; 65862-058; 16571-213; 63187-878; 0143-9667; 67405-602; 55154-7875; 65862-061; 68462-119; 0172-5413; 63629-8749; 57237-004; 62207-008; 68788-7150; 0049-3430; 71205-283; 70985-014; 71335-0769; 70518-2087; 63629-1949; 43063-326; 0143-9899; 0049-3500; 68084-735; 68071-4386; 70771-1066; 61919-493; 71205-650; 50268-337; 70518-3111; 68001-251; 60760-113; 55700-916; 61919-333; 68788-7621; 50090-5764; 57237-005; 53104-7522; 68788-7293; 68001-254; 65862-297; 63187-613; 70771-1064; 16714-694; 53002-1198; 63629-9134; 50090-3196; 70518-3100; 55700-521; 68788-7888; 55289-824; 68462-101; 71205-094; 13371-418
Synonyms Fluconazole | Zonal | Béagyne | Diflucan | Fluc Hexal | Flucobeta | FlucoLich | Fluconazol AbZ | Fluconazol AL | Fluconazol Stada | Fluconazol von ct | Fluconazol-Isis | Fluconazol Isis | Fluconazol-ratiopharm | Fluconazol ratiopharm | Flunazul | Fungata | Lavisa | Loitin | Neofomiral | Oxifungol | Solacap | UK-49858 | UK 49858 | UK49858 | Triflucan | Apo-Fluconazole | Apo Fluconazole
Chemical Information
Molecular Formula C13H12F2N6O
CAS Registry Number 86386-73-4
SMILES C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HypersensitivityLanosterol 14-alpha demethylaseQ8K0C4Not Available9797228; 12019078; 11864952; 10390213
HypersensitivityATP-dependent bile acid permeaseP32386Not Available9797228; 12019078; 11864952; 10390213
HypersensitivityATP-dependent translocase ABCB1P08183T252589797228; 12019078; 11864952; 10390213
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary alveolar haemorrhage24.07.01.015; 22.01.02.0050.000928%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary haemorrhage24.07.01.016; 22.02.04.0030.000206%
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.0030.002372%
Rash23.03.13.0010.004641%Not Available
Rash erythematous23.03.06.0030.000928%Not Available
Rash generalised23.03.13.0020.001753%Not Available
Rash macular23.03.13.0030.000206%Not Available
Rash maculo-papular23.03.13.0040.001031%
Rash pruritic23.03.12.0020.001341%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Renal failure20.01.03.005--Not Available
Renal pain20.02.03.003--Not Available
Renal tubular necrosis20.01.07.0030.000309%Not Available
Respiratory distress22.02.01.0120.000309%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Retroperitoneal fibrosis20.06.01.006; 10.02.01.026; 07.07.03.0030.000412%Not Available
Rhabdomyolysis15.05.05.002--
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.0040.000188%Not Available
Shock24.06.02.0020.000309%Not Available
Skin discolouration23.03.03.0050.000309%Not Available
Skin disorder23.03.03.007--Not Available
Skin erosion23.07.03.0020.000206%Not Available
Skin exfoliation23.03.07.0030.000928%Not Available
Skin hyperpigmentation23.05.01.0030.000722%
Skin infection23.09.04.002; 11.01.12.0030.000206%
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