Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluconazole
Drug ID BADD_D00912
Description Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.[A174325]
Indications and Usage For the treatment of fungal infections.
Marketing Status Prescription; Discontinued
ATC Code D01AC15; J02AC01
DrugBank ID DB00196
KEGG ID D00322
MeSH ID D015725
PubChem ID 3365
TTD Drug ID D09LNI
NDC Product Code 51407-424; 55111-144; 51407-301; 53104-7569; 70934-783; 70985-015; 16571-210; 68071-2557; 63187-584; 63275-9960; 68071-2347; 65862-059; 50090-0869; 51686-0006; 66039-857; 63629-8970; 67405-601; 70710-1137; 16714-691; 0395-8036; 55700-945; 51407-299; 51407-302; 55154-3400; 51407-300; 53002-4198; 65862-060; 51407-425; 57237-003; 50090-4426; 51407-426; 68071-4651; 62559-990; 68462-104; 0172-5412; 0172-5410; 72189-143; 63187-096; 0143-9668; 63629-1950; 16571-211; 50090-3899; 68071-4002; 43063-642; 68071-4501; 55289-148; 71335-1268; 71335-0686; 51672-4066; 52343-087; 68071-2436; 71205-563; 70771-1065; 52343-085; 51672-4065; 50090-4425; 0049-3410; 63629-1948; 0904-6500; 38779-2442; 71335-1037; 70710-1140; 50090-2195; 55111-145; 59762-5018; 68071-2609; 57237-149; 52343-086; 71205-081; 70985-016; 16571-212; 61919-380; 51927-3783; 0049-3450; 70518-0560; 62559-993; 25021-184; 52343-088; 72789-209; 72189-149; 76420-164; 50090-5299; 70710-1138; 60760-804; 16714-696; 70518-3312; 0143-9669; 70934-935; 16714-692; 50268-339; 65862-299; 51672-4067; 71335-1511; 63629-1947; 0049-3440; 0338-6045; 50090-3194; 68084-728; 64567-0002; 59762-5017; 67405-604; 70771-1063; 65862-300; 68071-2601; 49452-3149; 59762-5016; 65427-025; 59762-5015; 72189-140; 61919-419; 57237-006; 72789-096; 51552-1031; 67405-603; 55111-039; 0904-6501; 53069-0380; 71335-0557; 60760-803; 0338-6046; 50090-4864; 65015-601; 70985-013; 62559-992; 71335-1954; 59762-5029; 70710-1139; 16714-693; 0049-3420; 71335-0764; 68788-7959; 70518-2415; 71335-1175; 68001-253; 0143-9666; 51655-435; 63629-8971; 71335-1895; 53002-4400; 63629-9091; 53002-2198; 70518-2411; 62559-991; 55111-146; 71335-1448; 65841-108; 71205-573; 68001-252; 71205-104; 51672-4064; 72189-342; 43063-645; 51407-427; 16714-695; 59762-5030; 70934-501; 71335-1948; 68462-102; 63629-7986; 55111-143; 0172-5411; 60592-209; 57237-150; 70518-3092; 62991-2651; 65862-058; 16571-213; 63187-878; 0143-9667; 67405-602; 55154-7875; 65862-061; 68462-119; 0172-5413; 63629-8749; 57237-004; 62207-008; 68788-7150; 0049-3430; 71205-283; 70985-014; 71335-0769; 70518-2087; 63629-1949; 43063-326; 0143-9899; 0049-3500; 68084-735; 68071-4386; 70771-1066; 61919-493; 71205-650; 50268-337; 70518-3111; 68001-251; 60760-113; 55700-916; 61919-333; 68788-7621; 50090-5764; 57237-005; 53104-7522; 68788-7293; 68001-254; 65862-297; 63187-613; 70771-1064; 16714-694; 53002-1198; 63629-9134; 50090-3196; 70518-3100; 55700-521; 68788-7888; 55289-824; 68462-101; 71205-094; 13371-418
Synonyms Fluconazole | Zonal | Béagyne | Diflucan | Fluc Hexal | Flucobeta | FlucoLich | Fluconazol AbZ | Fluconazol AL | Fluconazol Stada | Fluconazol von ct | Fluconazol-Isis | Fluconazol Isis | Fluconazol-ratiopharm | Fluconazol ratiopharm | Flunazul | Fungata | Lavisa | Loitin | Neofomiral | Oxifungol | Solacap | UK-49858 | UK 49858 | UK49858 | Triflucan | Apo-Fluconazole | Apo Fluconazole
Chemical Information
Molecular Formula C13H12F2N6O
CAS Registry Number 86386-73-4
SMILES C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HypersensitivityATP-dependent translocase ABCB1P08183T252589797228; 12019078; 11864952; 10390213
HypersensitivityLanosterol 14-alpha demethylaseQ8K0C4Not Available9797228; 12019078; 11864952; 10390213
HypersensitivityATP-dependent bile acid permeaseP32386Not Available9797228; 12019078; 11864952; 10390213
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Gynaecomastia21.05.04.003; 05.05.02.0030.000206%
Haematuria24.07.01.047; 20.02.01.0060.000516%
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.0060.000309%Not Available
Hallucination19.10.02.0020.000928%
Hallucination, visual19.10.02.0040.000516%Not Available
Headache17.14.01.001--
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.000108%Not Available
Hepatic failure09.01.03.0020.000135%
Hepatic function abnormal09.01.02.0010.000928%Not Available
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.0040.000412%Not Available
Hepatocellular injury09.01.07.008--Not Available
Hepatosplenomegaly09.01.05.002; 01.09.03.0010.000206%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.000722%Not Available
Herpes simplex23.09.03.001; 11.05.02.001--Not Available
Hyperaemia24.03.02.0020.000309%Not Available
Hyperaesthesia17.02.06.0040.000309%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.0020.000412%
Hypercholesterolaemia14.08.01.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hyperkinesia17.01.02.008--Not Available
Hyperpyrexia08.05.02.0020.000309%Not Available
Hypersensitivity10.01.03.0030.001134%
Hypertension24.08.02.0010.001444%
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypertriglyceridaemia14.08.02.001--
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