Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fexofenadine hydrochloride
Drug ID BADD_D00894
Description Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms.[L4269] It is selective for the H1 receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation antihistamines, such as [diphenhydramine], which readily bind to off-targets that contribute to side effects such as sedation.[A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a racemic mixture in which both enantiomers display approximately equivalent antihistamine activity.[L10779]
Indications and Usage For management of Seasonal allergic rhinitis
Marketing Status Prescription; OTC; Discontinued
ATC Code R06AX26
DrugBank ID DB00950
KEGG ID D00671
MeSH ID C093230
PubChem ID 63002
TTD Drug ID D01KPV
NDC Product Code 55111-783; 70518-2971; 58602-710; 55301-847; 11673-617; 62011-0409; 50594-769; 68016-995; 46438-0638; 62207-765; 0113-0847; 51686-0001; 66577-021; 63868-334; 41167-4122; 69848-002; 69842-052; 62756-542; 12579-182; 46122-462; 62993-0809; 58175-0616; 63868-025; 43598-809; 68196-107; 63940-769; 50090-1234; 36800-653; 72036-192; 71796-015; 54257-170; 41163-292; 12579-189; 49348-968; 73581-011; 65862-966; 68016-176; 68016-887; 62756-545; 53104-7583; 68998-192; 49035-995; 55111-782; 57344-192; 72969-028; 11822-0425; 79481-0847; 61919-536; 36800-652; 46122-387; 65096-0103; 51927-0044; 41167-4244; 68210-2210; 53360-1109; 72476-847; 45802-571; 41250-784; 51672-2121; 73581-103; 36800-954; 53943-392; 68016-769; 21130-784; 68210-0122; 17404-0019; 41163-571; 51672-2119; 46438-1111; 11673-571; 68071-5191; 44657-0078; 0363-0097; 0480-7253; 49035-366; 55111-784; 68001-440; 36800-691; 0363-0783; 68001-439; 69842-492; 55111-023; 45802-847; 51927-0016; 56062-847; 64679-982; 12579-188; 68998-292; 63981-847; 70000-0586; 62011-0413; 55910-571; 63981-571; 65372-1167; 60000-409; 46438-0107; 12854-915; 43598-054; 70000-0361; 11822-3698; 52904-190; 77777-113; 71335-0721; 62207-766; 10202-229; 62756-543; 68071-2504; 41167-4131; 65977-0060; 70677-0074; 46438-0651; 49035-784; 58602-711; 0363-0784; 68391-847; 41167-4124; 72288-847; 0363-0095; 37808-571; 11822-0571; 70518-1702; 68071-1896; 63187-334; 67751-033; 82348-104; 41167-4120; 36800-319; 65015-894; 64679-744; 53943-021; 55319-917; 66715-9707; 64679-987; 71610-292; 41167-4232; 72036-292; 0480-7252; 43598-936; 0363-9898; 72476-192; 0113-0571; 41167-4121; 53360-1106; 46438-0637; 55910-111; 55315-355; 63868-667; 37808-847; 62207-002; 54257-001; 68210-4090; 71335-0483; 57344-292; 43598-577; 43063-337; 63940-768; 68196-976; 71309-091; 70692-134; 53943-192; 30142-878; 10202-107; 0904-6711; 54257-702; 70518-1218
Synonyms fexofenadine | alpha-(4-(1-carboxy-1-methylethyl)phenyl)-4-hydroxydiphenylmethyl-1-piperidinebutanol | fexofenadine hydrochloride | MDL 16.455 | MDL-16455 | MDL 16455 | Allegra | Telfast | MDL 16,455A
Chemical Information
Molecular Formula C32H40ClNO4
CAS Registry Number 153439-40-8
SMILES CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Back pain15.03.04.005--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Cough22.02.03.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Influenza22.07.02.001; 11.05.03.001--Not Available
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Myalgia15.05.02.001--
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Nightmare19.02.03.003--Not Available
Otitis media11.01.05.004; 04.05.01.001--
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rhinorrhoea22.02.05.010--
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