Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fentanyl citrate
Drug ID BADD_D00880
Description Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia.[A179542] Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin.[A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths).[L6748] Opioid overdoses kill an average of 11 Canadians daily.[L6751] Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Indications and Usage For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy.
Marketing Status Prescription; Discontinued
ATC Code N01AH01; N02AB03
DrugBank ID DB00813
KEGG ID D01399
MeSH ID D005283
PubChem ID 13810
TTD Drug ID D0E1WI
NDC Product Code 0406-9202; 64181-0007; 0641-6026; 0641-6247; 0406-9216; 63459-516; 63275-5100; 51552-0687; 0641-6028; 0641-6030; 59116-3281; 63323-806; 63459-512; 51862-636; 0641-6027; 0641-6025; 0093-7865; 51862-634; 63323-817; 0093-7869; 63323-808; 49452-0032; 51862-635; 63459-506; 51927-0042; 0406-9208; 0406-1344; 0409-1276; 42358-200; 0406-1130; 38779-1756; 59116-3282; 59116-3280; 0641-6024; 0093-7867; 62991-1405; 0641-6029; 72572-171; 0093-7868; 0409-9094; 61960-9500; 17478-030; 0409-9093; 0406-9204; 63459-508; 0406-9206; 51862-637; 63459-504; 81371-2010; 0406-9212; 49812-0001; 0406-1333; 0093-7870; 0406-1205; 63459-502; 72572-170; 82393-118; 51862-638; 72572-172; 0093-7866; 17478-031
Synonyms Fentanyl | Phentanyl | Fentanest | Fentanyl Citrate | R-4263 | R 4263 | R4263 | Sublimaze | Transmucosal Oral Fentanyl Citrate | Duragesic | Durogesic | Fentora
Chemical Information
Molecular Formula C28H36N2O8
CAS Registry Number 990-73-8
SMILES CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug tolerance increasedAdenylate cyclase type 1Q08828T63609Not Available
Drug tolerance increasedMu-type opioid receptorP35372T47768Not Available
PainOpioid growth factor receptorQ9NZT2T13741Not Available
PainAbscisic acid-inducible protein kinaseQ02066Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Abscess11.01.08.001--Not Available
Accidental overdose12.06.03.002--Not Available
Acidosis14.01.03.002--
Agitation19.06.02.001; 17.02.05.012--
Akathisia19.06.02.006; 17.01.02.002--
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Anorectal disorder07.03.01.001--Not Available
Anxiety19.06.02.002--
Aphthous ulcer07.05.06.002--Not Available
Apnoea22.02.01.001--
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Application site ulcer12.07.01.007; 08.02.01.007; 23.07.03.010--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Back pain15.03.04.005--
Bleeding time prolonged13.01.02.002--Not Available
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