Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethambutol
Drug ID BADD_D00841
Description Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis.[L31743] Ethambutol was first described in the literature in 1961.[A229048] It was developed out of a need for therapies active against isoniazid resistant strains of _Mycobacterium tuberculosis_.[A229048] Ethambutol was granted FDA approval on 6 November 1967.[L31663]
Indications and Usage For use, as an adjunct, in the treatment of pulmonary tuberculosis.
Marketing Status Prescription; Discontinued
ATC Code J04AK02
DrugBank ID DB00330
KEGG ID D07925
MeSH ID D004977
PubChem ID 14052
TTD Drug ID D08QME
NDC Product Code 60592-243
Synonyms Ethambutol | Dexambutol | Etibi | EMB-Fatol | EMB Fatol | Etambutol Llorente | Llorente, Etambutol | Ethambutol Hydrochloride | Hydrochloride, Ethambutol | Myambutol | Miambutol | EMB-Hefa | EMB Hefa
Chemical Information
Molecular Formula C10H24N2O2
CAS Registry Number 74-55-5
SMILES CCC(CO)NCCNC(CC)CO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Visual impairment06.02.06.0080.011478%Not Available
Vitamin K deficiency14.12.03.0050.004591%Not Available
Vomiting07.01.07.0030.004591%
Weight increased13.15.01.0060.004591%
Musculoskeletal discomfort15.03.04.001--Not Available
Major depression19.15.01.0030.004591%Not Available
Optic nerve disorder17.04.05.004; 06.02.08.001--
Decreased appetite14.03.01.005; 08.01.09.0280.004591%
Ill-defined disorder08.01.03.049--Not Available
Gastrointestinal tract irritation07.08.03.008--Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.004591%Not Available
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 23.03.05.0050.004591%Not Available
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