Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Estramustine
Drug ID BADD_D00826
Description A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Indications and Usage For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate
Marketing Status Prescription
ATC Code L01XX11
DrugBank ID DB01196
KEGG ID D04066
MeSH ID D004961
PubChem ID 259331
TTD Drug ID D03SRY
NDC Product Code Not Available
Synonyms Estramustine | Estracyt | Estramustine Phosphate Sodium | Phosphate Sodium, Estramustine | Leo-275 | Leo 275 | Leo275 | NSC-89199 | NSC 89199 | NSC89199 | Emcyt | Estramustinphosphate | Estramustin Phosphate | Phosphate, Estramustin
Chemical Information
Molecular Formula C23H31Cl2NO3
CAS Registry Number 2998-57-4
SMILES CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Libido decreased21.03.02.005; 19.08.03.001--
Liver function test abnormal13.03.01.013--Not Available
Menopausal symptoms21.02.02.002--Not Available
Mood swings19.04.03.001--Not Available
Muscle spasms15.05.03.004--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Night sweats23.02.03.006; 08.01.03.031--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pancytopenia01.03.03.003--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Skin exfoliation23.03.07.003--Not Available
Tenderness08.01.08.005--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Throat irritation07.05.03.004; 22.02.05.013--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Vomiting07.01.07.003--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Affect lability19.04.01.001--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Embolism24.01.01.009--
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Bone marrow failure01.03.03.005--
Gastrointestinal tract irritation07.08.03.008--Not Available
Liver function test increased13.03.01.044--Not Available
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