Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eribulin
Drug ID BADD_D00798
Description Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of advanced solid tumors [A7439].
Indications and Usage For the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic cancer.
Marketing Status Prescription
ATC Code L01XX41
DrugBank ID DB08871
KEGG ID D08914
MeSH ID C490954
PubChem ID 11354606
TTD Drug ID D0XQ5X
NDC Product Code Not Available
Synonyms eribulin | E 7389 | E-7389 | ER-086526 | ER086526 | ER 086526 | ER-86526 | Halaven | NSC 707389 | NSC707389 | NSC-707389 | B 1793 | B-1793 | B 1939 | B-1939 | eribulin mesylate | eribulin monomethanesulfonate | eribulin mesilate | eribulin (as mesylate)
Chemical Information
Molecular Formula C40H59NO11
CAS Registry Number 253128-41-5
SMILES CC1CC2CCC3C(=C)CC(O3)CCC45CC6C(O4)C7C(O6)C(O5)C8C(O7)CCC(O8)CC(=O)CC9C(CC(C1=C)O 2)OC(C9OC)CC(CN)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Malaise08.01.01.0030.007460%
Meningitis17.06.03.001; 11.01.03.0010.000533%
Menopausal symptoms21.02.02.002--Not Available
Metastases to liver09.04.02.004; 16.22.02.0010.000208%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Mucosal inflammation08.01.06.0020.003996%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.0010.002664%
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myelodysplastic syndrome16.01.04.001; 01.10.04.0010.000139%
Myocardial infarction24.04.04.009; 02.02.02.007--
Myopathy15.05.05.0010.000533%Not Available
Nail disorder23.02.05.002--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.0090.001066%
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.0030.014919%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.001066%Not Available
Neutropenia01.02.03.0040.062074%Not Available
Neutrophil count decreased13.01.06.0100.002398%
Night sweats23.02.03.006; 08.01.03.031--Not Available
Oedema14.05.06.010; 08.01.07.0060.001332%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.001865%
Oral candidiasis11.03.03.004; 07.05.07.0010.001066%Not Available
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