Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ergotamine
Drug ID BADD_D00796
Description A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Indications and Usage For use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".
Marketing Status Prescription; Discontinued
ATC Code G02AB02; N02CA02
DrugBank ID DB00696
KEGG ID D07906
MeSH ID D004878
PubChem ID 8223
TTD Drug ID D01TSI
NDC Product Code Not Available
Synonyms Ergotamine | Ergomar | Ergostat | Ergotamine Tartrate | Tartrate, Ergotamine | Ergotamine Tartrate (2:1) | Ergotaminine | Ergo-Kranit | Ergo Kranit | Lingraine | Cornutamine | Ergo Sanol | Ergodryl Mono | Mono, Ergodryl | Gynergen
Chemical Information
Molecular Formula C33H35N5O5
CAS Registry Number 379-79-3
SMILES CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C 6=C5)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Gangrene23.06.06.001; 11.02.01.003; 24.04.05.003--Not Available
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Myalgia15.05.02.001--
Nausea07.01.07.001--
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Peripheral coldness08.01.09.010; 24.04.03.006--Not Available
Pruritus23.03.12.001--
Pulse absent13.14.04.005--Not Available
Sensory loss17.02.07.007--Not Available
Tachycardia02.03.02.007--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.003--
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.006--
Emotional distress19.04.02.008--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Ischaemia24.04.02.004--Not Available
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