Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dizziness postural24.06.02.008; 17.02.05.004; 02.01.02.0050.000371%Not Available
Drug hypersensitivity10.01.01.001--Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.004--Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.0010.001484%
Dysphagia07.01.06.003--
Dyspnoea02.01.03.002; 22.02.01.0040.038955%
Dyspnoea at rest02.01.03.007; 22.02.01.0250.000742%Not Available
Dyspnoea exertional22.02.01.005; 02.01.03.0030.005565%Not Available
Ear infection11.01.05.001; 04.03.01.0060.001113%Not Available
Ear pain04.03.01.0030.000371%
Eczema23.03.04.006--
Electrocardiogram ST segment elevation13.14.05.0250.000371%Not Available
Electrolyte imbalance14.05.01.0020.000371%Not Available
Encephalopathy17.13.02.001--
Endocarditis11.01.16.001; 02.09.01.0010.000145%
Endocrine disorder05.09.01.001--Not Available
Eosinophilia01.02.04.0010.001855%
Epistaxis24.07.01.005; 22.04.03.0010.002411%
Erythema23.03.06.0010.003153%Not Available
Faeces discoloured07.01.03.0020.000556%Not Available
Fatigue08.01.01.0020.008718%
Feeling abnormal08.01.09.0140.003339%Not Available
Feeling cold08.01.09.0080.000556%Not Available
Feeling hot08.01.09.0090.001298%Not Available
Flatulence07.01.04.0020.000556%
Fluid overload14.05.06.001; 02.05.04.0040.004452%Not Available
Fluid retention20.01.02.003; 14.05.06.0020.010759%Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 15 Pages