Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status approved
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 66215-402; 62756-060; 66215-403; 62287-123; 62756-059
UNII DCR9Z582X0
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema23.03.06.0010.001341%Not Available
Eye pain06.08.03.0020.000164%
Eye swelling06.08.03.0030.000123%Not Available
Facial pain08.01.08.0120.000222%
Facial paralysis17.04.03.0080.000082%Not Available
Faeces discoloured07.01.03.0020.000263%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000082%Not Available
Fatigue08.01.01.0020.004458%
Feeling abnormal08.01.09.0140.001480%Not Available
Feeling cold08.01.09.0080.000345%Not Available
Feeling hot08.01.09.0090.000469%Not Available
Feeling jittery08.01.09.0160.000181%Not Available
Flatulence07.01.04.0020.000222%
Fluid retention20.01.02.003; 14.05.06.0020.003569%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.005658%
Food poisoning12.03.01.024; 11.07.02.001; 07.11.01.0070.000164%Not Available
Gallbladder disorder09.03.02.0010.000164%Not Available
Gastric cancer16.13.03.001; 07.21.02.0010.000082%Not Available
Gastric haemorrhage24.07.02.007; 07.12.01.0010.000206%
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.0030.000502%
Gastrointestinal disorder07.11.01.0010.000798%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.000864%Not Available
Gastrointestinal pain07.01.05.005--
Generalised oedema14.05.06.007; 08.01.07.0040.000082%
Goitre14.11.01.008; 05.02.01.0010.000592%Not Available
Gout15.01.06.001; 14.09.01.0010.000263%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000247%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.000206%Not Available
Haematoma24.07.01.0010.000428%
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