Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood culture positive13.08.02.0020.002040%Not Available
Blood glucose decreased13.02.02.0010.000556%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood iron decreased13.11.01.0060.000556%Not Available
Blood potassium decreased13.11.01.0100.001484%Not Available
Blood pressure abnormal13.14.03.0010.000371%Not Available
Blood pressure decreased13.14.03.0020.001669%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood sodium decreased13.11.01.0120.001113%Not Available
Blood thyroid stimulating hormone decreased13.10.03.0110.001113%Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.0010.000556%
Bradycardia02.03.02.002--Not Available
Breast cancer21.05.01.003; 16.10.01.0010.000556%Not Available
Bronchitis22.07.01.001; 11.01.09.0010.001669%
Bronchospasm22.03.01.004; 10.01.03.0120.000371%
Burning sensation17.02.06.001; 08.01.09.029--Not Available
C-reactive protein increased13.09.01.0070.000371%Not Available
Cardiac arrest02.03.04.0010.000629%
Cardiac failure02.05.01.0010.001403%
Cardiac failure acute02.05.01.0050.000097%Not Available
Cardiac failure congestive02.05.01.0020.003339%Not Available
Cardiac failure high output02.05.01.0100.000556%Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000339%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000194%Not Available
Cardiomegaly02.04.02.0010.000145%Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.0010.002597%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.001855%Not Available
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